Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

被引：32

作者：

Liu, Bo ^{[1
,2
,3
]}

Yang, Tao ^{[1
]}

Luo, Yi ^{[4
]}

Zeng, Linna ^{[1
,2
]}

Shi, Limin ^{[1
,2
]}

Wei, Chengxi ^{[1
]}

Nie, Ying ^{[1
]}

Cheng, Yu ^{[1
,2
]}

Lin, Qinlu ^{[1
]}

Luo, Feijun ^{[1
,2
]}

机构：

[1] Cent South Univ Forestry & Technol, Lab Mol Nutr, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China

[2] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Coll Food Sci & Engn, Key Lab Special Med Food Proc Hunan Prov, Changsha 410004, Hunan, Peoples R China

[3] Hunan Univ Chinese Med, Coll Pharm, Changsha 410004, Hunan, Peoples R China

[4] Cent S Univ, Xiangya Sch Med, Coll Clin Med, Changsha 410008, Hunan, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 41卷

基金：

中国国家自然科学基金;

关键词：

Oat beta-glucan; Hyperlipidemia; Steatosis; AMPK; ACTIVATED PROTEIN-KINASE; ACID-INDUCED STEATOSIS; EMERGING DRUG TARGET; PPAR-ALPHA; NONALCOHOLIC STEATOHEPATITIS; TRANSCRIPTION FACTOR; LIPID-ACCUMULATION; ULCERATIVE-COLITIS; OXIDATIVE STRESS; CORONARY-ARTERY;

D O I：

10.1016/j.jff.2017.12.045

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

To evaluate the lowering-lipid effect of oat beta-glucan (O beta G) and its molecular mechanism, high-fat diet (HFD)-induced hyperlipidemic mouse model and oleic acid-induced lipid accumulation model of HepG2 cells were used in this study. O beta G obviously reduced HFD-induced the gain of body weight and epididymal fat pad, and inhibited hepatic adipocyte hyperplasia. These effects were associated with the down-regulation of FAS and SREBP-1, up-regulation of PPAR alpha and particularly the activation of AMP-activated protein kinase (AMPK) signaling in both liver and fat tissues. In the oleic acid-induced HepG2 cells, O beta G partly suppressed lipogenesis and activated AMPK. O beta G inhibited lipid metabolism-related protein expressions such as FAS, SREBP-1, CPT-1, PPAR alpha and activating ACC, which are the downstream targets of AMPK. Taken together, our results suggest that administration of O beta G exerts lipid-lowering effect in HFD mice via AMPK signal pathway, which provide novel application for the prevention and treatment of hyperlipidemia.

引用

页码：72 / 82

页数：11

共 65 条

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