Trimethylsilyl Trifluoromethanesulfonate-Accelerated Addition of Catalytically Generated Zinc Acetylides to Aldehydes

被引：31

作者：

Downey, C. Wade ^{[1
]}

Mahoney, Brian D. ^{[1
]}

Lipari, Vincent R. ^{[1
]}

机构：

[1] Univ Richmond, Gottwald Ctr Sci, Richmond, VA 23173 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 07期

关键词：

PROPARGYLIC ALCOHOLS; TERMINAL ALKYNES; ENANTIOSELECTIVE SYNTHESIS; ACETYLENES; KETONES; FACILE; TMSOTF;

D O I：

10.1021/jo900102w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of TMSOTf, a wide variety of terminal acetylenes add rapidly and efficiently to aldehydes via a catalytically generated zinc acetylide. In the absence of TMSOTf, no reaction is observed under otherwise identical conditions.

引用

页码：2904 / 2906

页数：3

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