Palladium-catalysed ortho-acylation of 6-anilinopurines/purine nucleosides via C-H activation

被引：16

作者：

Allu, Srinivasarao ^{[1
]}

Swamy, K. C. Kumara ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Telangana, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 112期

关键词：

ALPHA-OXOCARBOXYLIC ACIDS; DECARBOXYLATIVE ORTHO-ACYLATION; OXIDATIVE ORTHO-ACYLATION; TERT-BUTYL HYDROPEROXIDE; TOLUENE DERIVATIVES; BOND ACTIVATION; DIRECTING GROUP; DIRECT ACCESS; 6-ARYLPURINE NUCLEOSIDES; AROMATIC-ALDEHYDES;

D O I：

10.1039/c5ra18447a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purinyl N1 directed ortho-acylation of 6-anilinopurines was achieved via C(sp(2))-H bond activation in the presence of [Pd]-catalyst using aldehydes or alpha-oxocarboxylic acids as the acylating source. A wide variety of purine appended 2'-aminoacetophenones/benzophenones are isolated in good to excellent yields. These catalytic transformations are also successfully applied to 6-anilinopurine nucleosides.

引用

页码：92045 / 92054

页数：10

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