cMET as a potential therapeutic target in gastric cancer

被引：23

作者：

Teng, Lisong ^{[1
]}

Lu, Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Surg Oncol, Hangzhou 310000, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2013年 / 32卷 / 06期

关键词：

cMET; gastric cancer; targeted therapy; cMET inhibitors; drug resistance; HEPATOCYTE GROWTH-FACTOR; C-MET RECEPTOR; TYROSINE KINASE; FACTOR/SCATTER FACTOR; TPR-MET; MEDIATES RESISTANCE; ACQUIRED-RESISTANCE; MOLECULAR-CLONING; SCATTER FACTOR; BINDING-SITE;

D O I：

10.3892/ijmm.2013.1531

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gastric cancer is one of the most common malignancies worldwide. Despite improvements in surgery and chemotherapy, the outcomes in patients with advanced gastric cancer remain poor. cMET is a member of the receptor tyrosine kinase family, and plays a key role in tumor survival, growth, angiogenesis and metastasis. cMET overexpression and/or gene amplification occurs in a significant proportion of gastric cancers. cMET is associated with a high tumor stage and poor prognosis. Several cMET inhibitors have been investigated in clinical trials, and the initial results are encouraging. It has become increasingly apparent that cMET is a promising therapeutic target in gastric cancer. In this review, we summarize the development of cMET inhibitors in the preclinical and clinical environment. In addition, we discuss the challenges of cMET-targeted therapy in gastric cancer and explore possible solutions.

引用

页码：1247 / 1254

页数：8

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