Structures and absolute configurations of the marine toxins, latrunculin A and laulimalide

被引:111
作者
Jefford, CW
Bernardinelli, G
Tanaka, J
Higa, T
机构
[1] UNIV GENEVA,CRYSTALLOG LAB,CH-1211 GENEVA 4,SWITZERLAND
[2] UNIV RYUKYUS,DEPT MARINE SCI,NISHIHARA,OKINAWA 90301,JAPAN
关键词
macrolide; fijianolide; 2-thiazolidinone; dihydropyran; X-ray;
D O I
10.1016/0040-4039(95)02113-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Latrunculin A (1) and laulimalide (2) were isolated from Fasciospongia rimosa collected in Okinawan waters. By purification, single crystals were obtained thereby enabling the absolute configurations of 1 and 2 to be determined by X-ray analysis.
引用
收藏
页码:159 / 162
页数:4
相关论文
共 12 条
[1]   LEAST-SQUARES ABSOLUTE-STRUCTURE REFINEMENT - PRACTICAL EXPERIENCE AND ANCILLARY CALCULATIONS [J].
BERNARDINELLI, G ;
FLACK, HD .
ACTA CRYSTALLOGRAPHICA SECTION A, 1985, 41 (SEP) :500-511
[2]  
BLUMBERG PM, 1992, ALFRED BENZON SYMP S, V33, P273
[3]   LAULIMALIDES - NEW POTENT CYTO-TOXIC MACROLIDES FROM A MARINE SPONGE AND A NUDIBRANCH PREDATOR [J].
CORLEY, DG ;
HERB, R ;
MOORE, RE ;
SCHEUER, PJ ;
PAUL, VJ .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (15) :3644-3646
[4]   MARINE TOXINS OF LATRUNCULIA-MAGNIFICA [J].
GROWEISS, A ;
SHMUELI, U ;
KASHMAN, Y .
JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (20) :3512-3516
[5]   ISOLATION OF LATRUNCULIN-A, 6,7-EPOXYLATRUNCULIN-A, FIJIANOLIDE-A, AND EURYFURAN FROM A NEW GENUS OF THE FAMILY THORECTIDAE [J].
GULAVITA, NK ;
GUNASEKERA, SP ;
POMPONI, SA .
JOURNAL OF NATURAL PRODUCTS, 1992, 55 (04) :506-508
[6]   MIYAKOLIDE - A BRYOSTATIN-LIKE MACROLIDE FROM A SPONGE, POLYFIBROSPONGIA SP [J].
HIGA, T ;
TANAKA, J ;
KOMESU, M ;
GRAVALOS, DG ;
PUENTES, JLF ;
BERNARDINELLI, G ;
JEFFORD, CW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (19) :7587-7588
[7]   LATRUNCULIN, A NEW 2-THIAZOLIDINONE MACROLIDE FROM THE MARINE SPONGE LATRUNCULIA-MAGNIFICA [J].
KASHMAN, Y ;
GROWEISS, A ;
SHMUELI, J .
TETRAHEDRON LETTERS, 1980, 21 (37) :3629-3632
[8]   LATRUNCULINS - NMR-STUDY, 2 NEW TOXINS AND A SYNTHETIC APPROACH [J].
KASHMAN, Y ;
GROWEISS, A ;
LIDOR, R ;
BLASBERGER, D ;
CARMELY, S .
TETRAHEDRON, 1985, 41 (10) :1905-1914
[10]   FIJIANOLIDES, POLYKETIDE HETEROCYCLES FROM A MARINE SPONGE [J].
QUINOA, E ;
KAKOU, Y ;
CREWS, P .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (15) :3642-3644