How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

被引：22
作者：
Frassetto, L. A. [1 ,2 ]
Sebastian, A. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Clin & Translat Sci Inst, San Francisco, CA 94143 USA
来源：
MEDICAL HYPOTHESES | 2012年 / 79卷 / 02期
关键词：
BONE-MINERAL DENSITY; HIP FRACTURE; LIPID-PEROXIDATION; CELLS; MELLITUS; INSULIN; RATS; IRON; PH; MICROARCHITECTURE;
D O I：
10.1016/j.mehy.2012.04.031
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：189 / 192
页数：4
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