How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects

被引：23

作者：

Frassetto, L. A. ^{[1
,2
]}

Sebastian, A. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Clin & Translat Sci Inst, San Francisco, CA 94143 USA

来源：

MEDICAL HYPOTHESES | 2012年 / 79卷 / 02期

关键词：

BONE-MINERAL DENSITY; HIP FRACTURE; LIPID-PEROXIDATION; CELLS; MELLITUS; INSULIN; RATS; IRON; PH; MICROARCHITECTURE;

D O I：

10.1016/j.mehy.2012.04.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：189 / 192

页数：4

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