Association Between TGF-β1 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

被引：11

作者：

Guo, Ying ^{[1
]}

Zang, Chunbao ^{[1
]}

Li, Yajun ^{[1
]}

Yuan, Li ^{[1
]}

Liu, Qingjun ^{[2
]}

Zhang, Lingyan ^{[3
]}

Li, Shaolin ^{[1
]}

机构：

[1] Chongqing Med Univ, Coll Basic Med, Dept Radiol, Chongqing 400016, Peoples R China

[2] Mianyang Cent Hosp, Dept Otolaryngol, Mianyang, Peoples R China

[3] Mianyang Cent Hosp, Dept Prevent & Hlth Care, Mianyang, Peoples R China

来源：

GENETIC TESTING AND MOLECULAR BIOMARKERS | 2013年 / 17卷 / 11期

基金：

中国国家自然科学基金;

关键词：

GROWTH-FACTOR-BETA; CYTOKINE GENE POLYMORPHISMS; HEPATITIS-B-VIRUS; TRANSFORMING GROWTH-FACTOR-BETA-1; PROGNOSIS; CIRRHOSIS; GENOTYPES;

D O I：

10.1089/gtmb.2013.0268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Associations between transforming growth factor (TGF)-1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations. Methods: We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results: A total of 14 studies were included in this meta-analysis. TGF-1 +869C/T polymorphism was significantly associated with HCC risk (OR=1.74, 95% CI: 1.22-2.47, p=0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR=1.40, 95% CI: 1.15-1.70, p=0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies. Conclusions: Our meta-analysis suggested that the TGF-1 +869C/T and -509C/T polymorphisms may be risk factors for developing HCC.

引用

页码：814 / 820

页数：7

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