Pediatric low-grade gliomas: How modern biology reshapes the clinical field

被引：53
作者：
Bergthold, Guillaume [1 ]
Bandopadhayay, Pratiti [1 ,6 ,7 ]
Bi, Wenya Linda [1 ]
Ramkissoon, Lori [4 ,5 ]
Stiles, Charles [1 ]
Segal, Rosalind A. [1 ,8 ]
Beroukhim, Rameen [1 ]
Ligon, Keith L. [4 ,5 ]
Grill, Jacques [2 ,3 ]
Kieran, Mark W. [6 ,7 ]
机构：
[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
[2] Univ Paris 11, Dept Cancerol Enfant & Adolescent, Villejuif, France
[3] Univ Paris 11, CNRS, Unite Mixte Rech 8203, Villejuif, France
[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[5] Dana Farber Canc Inst, Ctr Mol Oncol Pathol, Boston, MA 02215 USA
[6] Dana Farber Canc Inst, Div Pediat Hematol & Oncol, Boston, MA 02215 USA
[7] Boston Childrens Hosp, Boston, MA USA
[8] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2014年 / 1845卷 / 02期
关键词：
Pediatric; Low-grade glioma; Genetics; BRAF; CENTRAL-NERVOUS-SYSTEM; JUVENILE PILOCYTIC ASTROCYTOMAS; MIB-1 LABELING INDEX; OPTIC PATHWAY GLIOMAS; BRAIN-STEM GLIOMAS; DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR; CONFORMAL RADIATION-THERAPY; ONCOGENE-INDUCED SENESCENCE; SINGLE-CENTER EXPERIENCE; PHASE-II TRIAL;
D O I：
10.1016/j.bbcan.2014.02.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：294 / 307
页数：14
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