An Efficient Route to Ethyl 5-Alkyl- (Aryl)-1H-1,2,4-triazole-3-carboxylates

被引：9

作者：

Chudinov, M. V. ^{[1
]}

Matveev, A. V. ^{[1
]}

Zhurilo, N. I. ^{[1
]}

Prutkov, A. N. ^{[1
]}

Shvets, V. I. ^{[1
]}

机构：

[1] Lomonosov Moscow Univ Fine Chem Technol, Biotechnol & Bionanotechnol Dept, Moscow, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

ACID-DERIVATIVES; CARBOETHOXYFORMIMIDATE; 1,2,4-TRIAZOLES;

D O I：

10.1002/jhet.1934

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient general route to the synthesis of 5-substituted 1H-1,2,4-triazole-3-carboxylates was developed. N-acylamidrazones were obtained from carboxylic acid hydrazides and ethyl thiooxamate or ethyl 2-ethoxy-2-iminoacetate hydrochloride and then were reacted with chloroanhydride of the same carboxylic acid. As the next step, diacylamidrazones were cyclized to 5-substituted 1H-1,2,4-triazole-3-carboxylates one pot in mild conditions.

引用

页码：1273 / 1277

页数：5

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