Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey

被引：22

作者：

Karacaer, Zehra ^{[1
]}

Cakir, Banu ^{[2
]}

Erdem, Hakan ^{[3
]}

Ugurlu, Kenan ^{[4
]}

Durmus, Gul ^{[5
]}

Ince, Nevin Koc ^{[6
]}

Ozturk, Cinar ^{[7
]}

Hasbun, Rodrigo ^{[8
]}

Batirel, Ayse ^{[9
]}

Yilmaz, Esmeray Mutlu ^{[10
]}

Bozkurt, Ilkay ^{[11
]}

Sunbul, Mustafa ^{[11
]}

Aynioglu, Aynur ^{[12
]}

Atilla, Aynur ^{[10
]}

Erbay, Ayse ^{[13
]}

Inci, Ayse ^{[14
]}

Kader, Cigdem ^{[13
]}

Tigen, Elif Tukenmez ^{[15
]}

Karaahmetoglu, Gokhan ^{[16
]}

Coskuner, Seher Ayten ^{[17
]}

Dik, Ebru ^{[17
]}

Tarakci, Huseyin ^{[18
]}

Tosun, Selma ^{[17
]}

Korkmaz, Fatime ^{[19
]}

Kolgelier, Servet ^{[20
]}

Karadag, Fatma Yilmaz ^{[21
]}

Erol, Serpil ^{[22
]}

Turker, Kamuran ^{[23
]}

Necan, Ceyda ^{[24
]}

Sahin, Ahmet Melih ^{[25
]}

Ergen, Pinar ^{[21
]}

Iskender, Gulsen ^{[26
]}

Korkmaz, Pinar ^{[27
]}

Eroglu, Esma Gulesen ^{[28
]}

Durdu, Yasemin ^{[29
]}

Ulug, Mehmet ^{[30
]}

Deniz, Suna Secil ^{[31
]}

Koc, Filiz ^{[31
]}

Alpat, Saygin Nayman ^{[32
]}

Oztoprak, Nefise ^{[33
]}

Evirgen, Omer ^{[34
]}

Sozen, Hamdi ^{[35
]}

Dogan, Mustafa ^{[36
]}

Kaya, Selcuk ^{[37
]}

Kaya, Safak ^{[38
]}

Altindis, Mustafa ^{[39
]}

Aslan, Emel ^{[40
]}

Tekin, Recep ^{[40
]}

Sezer, Busra Ergut ^{[36
]}

Ozdemir, Kevser ^{[41
]}

机构：

[1] Etimesgut Mil Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Inst Publ Hlth, Ankara, Turkey

[3] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[4] 25 Aralik State Hosp, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey

[5] Sevket Yilmaz Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Bursa, Turkey

[6] Duzce Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Duzce, Turkey

[7] Recep Tayyip Erdogan Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Rize, Turkey

[8] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Infect Dis, Houston, TX 77030 USA

[9] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[10] Samsun Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Samsun, Turkey

[11] Ondokuz Mayis Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Samsun, Turkey

[12] Ataturk State Hosp, Dept Infect Dis & Clin Microbiol, Zonguldak, Turkey

[13] Bozok Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Yozgat, Turkey

[14] Kanuni Sultan Suleyman Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[15] Marmara Univ, Dept Infect Dis & Clin Microbiol, Pendik Training & Res Hosp, Istanbul, Turkey

[16] Haydarpasa Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Gulhane Mil Med Acad, Istanbul, Turkey

[17] Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey

[18] Izmir Metropolitan Municipal Esrefpasa Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey

[19] Konya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Konya, Turkey

[20] Yildirim Beyazit Univ, Dept Infect Dis & Clin Microbiol, Ankara Ataturk Training & Res Hosp, Ankara, Turkey

[21] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[22] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[23] Bagcilar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[24] Pamukkale Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Denizli, Turkey

[25] Giresun State Hosp, Dept Infect Dis & Clin Microbiol, Giresun, Turkey

[26] Ankara Oncol Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[27] Dumlupinar Univ, Dept Infect Dis & Clin Microbiol, Evliya Celebi Training & Res Hosp, Kutahya, Turkey

[28] Necmettin Erbakan Univ, Dept Infect Dis & Clin Microbiol, Meram Sch Med, Konya, Turkey

[29] Eyup State Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey

[30] Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey

[31] Kecioren Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[32] Osmangazi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Eskisehir, Turkey

[33] Antalya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey

[34] Mustafa Kemal Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Antakya, Turkey

[35] Sitki Kocman Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Mugla, Turkey

[36] Corlu State Hosp, Dept Infect Dis & Clin Microbiol, Tekirdag, Turkey

[37] Karadeniz Tech Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Trabzon, Turkey

[38] Gazi Yasargil Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey

[39] Sakarya Univ, Dept Clin Microbiol, Sch Med, Sakarya, Turkey

[40] Dicle Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Diyarbakir, Turkey

[41] Denizli State Hosp, Dept Infect Dis & Clin Microbiol, Denizli, Turkey

[42] Mersin Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Mersin, Turkey

[43] Gaziantep Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Gaziantep, Turkey

[44] Kayseri Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey

[45] Kafkas Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Kars, Turkey

[46] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey

[47] Sani Konukoglu Hosp, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey

[48] Karsikaya State Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey

[49] Ataturk Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Erzurum, Turkey

[50] Trabzon Kanuni Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey

来源：

HEALTH AND QUALITY OF LIFE OUTCOMES | 2016年 / 14卷

关键词：

Chronic hepatitis B infection; Quality of life; The Hepatitis B Quality of Life Instrument; Turkey; MARITAL-STATUS; HEALTH; COMORBIDITIES; IMPACT; DETERMINANTS; UTILITIES;

D O I：

10.1186/s12955-016-0557-9

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

引用

页数：10

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