Estrogen Regulation of Proteins in the Rat Ventromedial Nucleus of the Hypothalamus

被引：6
|
作者：
Mo, Bing [1 ,2 ]
Callegari, Eduardo [3 ]
Telefont, Martin [1 ,2 ]
Renner, Kenneth J. [1 ,2 ]
机构：
[1] Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA
[2] Univ S Dakota, Neurosci Grp, Vermillion, SD 57069 USA
[3] Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD 57069 USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2008年 / 7卷 / 11期
关键词：
Estradiol; Rat; Ventromedial Hypothalamus;
D O I：
10.1021/pr8005974
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of estradiol (E-2) on the expression of proteins in the pars lateralis of the ventromedial nucleus of the hypothalamus (VMNpl) in ovariectomized rats was studied using 2-dimensional gel electrophoresis followed by RPLC-nanoESI-MS/MS. E-2 treatment resulted in the up-regulation of 29 identified proteins. Many of these proteins are implicated in the promotion of neuronal plasticity and signaling.
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页码：5040 / 5048
页数：9
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