Ozone Therapy Ameliorates Nervous System Disorders and Oxidative Stress in Patients During Ethanol Withdrawal-A Pilot Study

被引：3

作者：

Teresa Diaz-Soto, Maria ^{[1
]}

Fraga Perez, Angela ^{[1
]}

Dranguet Vaillant, Jaqueline ^{[1
]}

Mallok, A. ^{[1
]}

Viebahn-Haensler, Renate ^{[2
]}

Menendez Cepero, Silvia ^{[3
]}

Leon Fernandez, Olga Sonia ^{[1
]}

机构：

[1] Univ Havana, Pharm & Food Inst, Havana 10400, Cuba

[2] Med Soc Use Ozone Prevent & Therapy, D-76473 Iffezheim, Germany

[3] Ozone Res Ctr, Havana 6412, Cuba

来源：

OZONE-SCIENCE & ENGINEERING | 2012年 / 34卷 / 06期

关键词：

Ozone; Ethanol Withdrawal; Oxidative Stress; Central Nervous System; ALCOHOL-WITHDRAWAL; NITRIC-OXIDE; CONSUMPTION; PROTECTION; DRINKING; DAMAGE;

D O I：

10.1080/01919512.2012.717858

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Chronic oxidative stress and acetaldehyde accumulation are associated with brain damage during Ethanol Withdrawal (EW). Ozone therapy is a regulator of cellular redox balance and it controls important functions of nervous system during EW at experimental level. The aim of this work was to develop a pilot study in order to evaluate the ozone's effects on EW signs and oxidative stress in 10 patients Before and After ozone treatments. Ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to Central Nervous System (CNS). Ozone's efficacy was observed in patients that required pharmacological treatment. Reduction of CIWA-Ar scores and the oxidative stress (p < 0.05) was demonstrated. In summary, ozone improved CNS functions and reduced oxidative stress in patients during EW. These results were according to experimental findings and suggest ozone's regulator effects on important neurotransmitters of the CNS.

引用

页码：432 / 437

页数：6

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