Tremulane sesquiterpenes from cultures of the basidiomycete Irpex lacteus

被引：13
|
作者：
Ding, Jian-Hai [1 ,2 ]
Li, Zheng-Hui [2 ]
Feng, Tao [2 ]
Liu, Ji-Kai [2 ]
机构：
[1] Ningxia Normal Univ, Coll Chem & Chem Engn, Engn & Technol Res Ctr Liupanshan Resources, Guyuan 756000, Ningxia, Peoples R China
[2] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
来源：
FITOTERAPIA | 2018年 / 125卷
关键词：
Irpex lacteus; Secondary metabolites; Tremulane sesquiterpenes; Cytotoxicity; CONOCYBE-SILIGINEA; FUNGUS;
D O I：
10.1016/j.fitote.2017.12.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new tremulane sesquiterpenes, named irlactins F-J (1-5), were isolated from cultures of the basidiomycete Irpex lacteus together with two known analogues (6 and 7). Structures and relative configurations of compounds 1-5 were elucidated by spectroscopic data analysis. Compund 4 exhibited moderate cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 16.23, 20.40, 25.55, 19.05, and 18.58 mu M, respectively.
引用
收藏
页码：245 / 248
页数：4
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