Emergence of NDM-5-and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata)

被引：115

作者：

Yang, Run-Shi ^{[1
,2
]}

Feng, Youjun ^{[3
]}

Lv, Xiao-Yue ^{[1
,2
]}

Duan, Jia-Hong ^{[1
,2
]}

Chen, Jing ^{[1
,2
]}

Fang, Liang-Xing ^{[1
,2
]}

Xia, Jing ^{[1
,2
]}

Liao, Xiao-Ping ^{[1
,2
]}

Sun, Jian ^{[1
,2
]}

Liu, Ya-Hong ^{[1
,2
]}

机构：

[1] South China Agr Univ, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou, Guangdong, Peoples R China

[2] South China Agr Univ, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet, Guangzhou, Guangdong, Peoples R China

[3] Zhejiang Univ, Sch Med, Dept Med Microbiol & Parasitol, Hangzhou, Zhejiang, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 11期

关键词：

CARBAPENEM-RESISTANT; MULTIDRUG-RESISTANCE; MCR-1; GENE; ENTEROBACTERIACEAE; VIRULENCE; SEQUENCE; FEATURES;

D O I：

10.1128/AAC.01365-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two Escherichia coli clones (sequence type 648 [ST648] and ST156) that coproduce NDM-5 and MCR-1 were detected from a single fowl in China. The bla(NDM-5) gene was found on the two indistinguishable IncX3 plasmids from the two different E. coli isolates, whereas the mcr-1 gene was located on IncHI2 and IncI2 plasmids, respectively, suggesting that bla(NDM-5) and mcr-1 have spread in avian intestinal flora. Also, the two strains harbor bla(TEM-1), bla(CTX-M-55,) fosA3, and aac(6')-Ib. The multiresistant E. coli strains (especially the epidemic clone ST648) might raise a potential threat to human health via food chain transmission.

引用

页码：6899 / 6902

页数：4

共 30 条

[1]

[Anonymous], SCAND J GASTROENTERO

[2] A GENERAL-METHOD FOR DETECTING AND SIZING LARGE PLASMIDS [J].

BARTON, BM ;

HARDING, GP ;

ZUCCARELLI, AJ .

ANALYTICAL BIOCHEMISTRY, 1995, 226 (02) :235-240

[3]

Clinical and Laboratory Standards Institute, 2015, M100S25 CLSI

[4] Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae [J].

Du, Hong ;

Chen, Liang ;

Tang, Yi-Wei ;

Kreiswirth, Barry N. .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :287-288

[5]

European Committee on Antimicrobial Susceptibility Testing [EUCAST], 2015, BREAKP TABL INT MICS

[6] CTX-M-15-D-ST648 Escherichia coli from companion animals and horses: another pandemic clone combining multiresistance and extraintestinal virulence? [J].

Ewers, Christa ;

Bethe, Astrid ;

Stamm, Ivonne ;

Grobbel, Mirjam ;

Kopp, Peter A. ;

Guerra, Beatriz ;

Stubbe, Michael ;

Doi, Yohei ;

Zong, Zhiyong ;

Kola, Axel ;

Schaufler, Katharina ;

Semmler, Torsten ;

Fruth, Angelika ;

Wieler, Lothar H. ;

Guenther, Sebastian .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (05) :1224-1230

[7] Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany [J].

Falgenhauer, Linda ;

Waersada, Said-Elias ;

Yao, Yancheng ;

Imirzalioglu, Can ;

Kaesbohrer, Annemarie ;

Roesler, Uwe ;

Michael, Geovana Brenner ;

Schwarz, Stefan ;

Werner, Guido ;

Kreienbrock, Lothar ;

Chakraborty, Trinad .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :282-283

[8] Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09) [J].

Gales, Ana C. ;

Jones, Ronald N. ;

Sader, Helio S. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (09) :2070-2074

[9] Genome sequence and characteristics of plasmid pWH12, a variant of the mcr-1-harbouring plasmid pHNSHP45, from the multi-drug resistant E-coli [J].

Gao, Rongsui ;

Wang, Qingjing ;

Li, Ping ;

Li, Zhencui ;

Feng, Youjun .

VIRULENCE, 2016, 7 (06) :732-735

[10] Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli [J].

Gao, Rongsui ;

Li, Yue ;

Lin, Jingxia ;

Tan, Chen ;

Feng, Youjun .

SCIENCE CHINA-LIFE SCIENCES, 2016, 59 (07) :732-734

← 1 2 3 →