Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol

被引:10
作者
Hosoyamada, Kaori [1 ]
Uto, Hirofumi [2 ]
Imamura, Yasushi [1 ]
Hiramine, Yasunari [1 ]
Toyokura, Eriko [1 ,2 ]
Hidaka, Yoshihiro [2 ]
Kuwahara, Tomomi [3 ]
Kusano, Ken [3 ]
Saito, Kazuto [4 ]
Oketani, Makoto [2 ]
Ido, Akio [2 ]
Tsubouchi, Hirohito [2 ]
机构
[1] Kagoshima Kouseiren Hosp, Dept Internal Med, Kagoshima 8900061, Japan
[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Kagoshima 8900061, Japan
[3] Kagoshima Kouseiren Med Hlth Care Ctr, Kagoshima 8900062, Japan
[4] Natl Inst Fitness & Sports Kanoya, Kanoya 8912393, Japan
关键词
Small dense low-density lipoprotein; Fatty liver; Type 2 diabetes mellitus; Metabolic syndrome; INSULIN-RESISTANCE; LDL-CHOLESTEROL; DYSLIPIDEMIA; METABOLISM; PARTICLES; DISEASE;
D O I
10.1186/1758-5996-4-34
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. Methods: We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays. Results: Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG < 150 mg/dl and LDL-C < 140 mg/dl; B, TG < 150 mg/dl and LDL-C >= 140 mg/dl; C, TG >= 150 mg/dl and LDL-C < 140 mg/dl; and D, TG >= 150 mg/dl and LDL-C >= 140 mg/dl. sd-LDL-C levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sd-LDL-C levels; the prevalence of fatty liver significantly increased with increasing sd-LDL-C levels. Additionally, logistic regression analysis revealed an independent association between sd-LDL-C concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDL-C levels. Conclusions: Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels.
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页数:7
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