Effect of polymerized human placenta hemoglobin on hemodynamic parameter and cardiac function in a rat hemorrhagic shock model

被引：6
|
作者：
Li, Tao [2 ,3 ]
Jiang, Yongxian [2 ,3 ]
Zhang, Zhenyu [1 ]
Zhang, Sisi [2 ,3 ]
Wu, Wei [4 ]
Liao, Daqin [2 ,3 ]
Chen, Yanfang [2 ,3 ]
Yang, Chengmin [5 ]
Xu, Xuewen [1 ]
Liu, Jin [2 ,3 ]
机构：
[1] Sichuan Univ, W China Hosp, Dept Burn & Plast Surg, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Hosp, Translat Neurosci Ctr, Chengdu 610041, Peoples R China
[3] Sichuan Univ, W China Hosp, Lab Anesthesiol, Chengdu 610041, Peoples R China
[4] Chengdu Army Gen Hosp, Dept Anesthesiol, Chengdu, Peoples R China
[5] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
来源：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2012年 / 40卷 / 04期
关键词：
Hemoglobin-based oxygen carrier; hemorrhagic shock; resuscitation; cardiac function; ISCHEMIA-REPERFUSION INJURY; ORGAN DYSFUNCTION; OXYGEN CARRIERS; NITRIC-OXIDE; RESUSCITATION; VASOCONSTRICTION; HBOC-201;
D O I：
10.3109/10731199.2012.663384
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group. Therefore, our findings suggest that PolyPHb moderately improved hemodynamic recovery and provided little cardioprotective effect in hemorrhagic shock.
引用
收藏
页码：256 / 260
页数：5
相关论文
共 50 条
  • [1] Polymerized human placenta hemoglobin improves resuscitative efficacy of hydroxyethyl starch in a rat model of hemorrhagic shock
    Li, Yaojin
    Yan, Dong
    Hao, Shasha
    Li, Shen
    Zhou, Wentao
    Wang, Hong
    Liu, Jiaxin
    Wang, Xiang
    Yang, Chengmin
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2015, 43 (03) : 174 - 179
  • [2] Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock
    Wang, Li
    Liu, Fang
    Yan, Kunping
    Pan, Wencan
    Xu, Lijuan
    Liu, Huifang
    Yan, Chengbin
    Chen, Chao
    Zhu, Hongli
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (01) : 51 - 57
  • [3] Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury
    Li, Tao
    Zhang, Zhenyu
    Wu, Wei
    Liao, Daqin
    Chen, Yanfang
    Li, Shen
    Yang, Chengmin
    Xu, Xuewen
    Liu, Jin
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2013, 41 (01) : 27 - 31
  • [4] Human polymerized hemoglobin as an alternative to blood in resuscitation from hemorrhagic shock
    Muller, Cynthia Rodrigues
    Williams, Alexander
    Faker, Allyn
    Sandoval, Jose
    Cuddington, Clayton
    Moses, Savannah
    Palmer, Andre
    Cabrales, Pedro
    FASEB JOURNAL, 2021, 35
  • [5] Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic
    Ao-ieong, Eilleen S. Y.
    Williams, Alexander
    Jani, Vivek
    Cabrales, Pedro
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (04) : 686 - 693
  • [6] The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock
    Zhao, Jing
    Yan, Chengbin
    Xu, Lijuan
    Yan, Kunping
    Feng, Bao
    Zhao, Mengye
    Niu, Geng
    Wu, Mengdi
    Chen, Chao
    Zhu, Hongli
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (04) : 677 - 685
  • [7] Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock
    Muller, Cynthia R.
    Williams, Alexander T.
    Walser, Cynthia
    Eaker, Allyn M.
    Sandoval, Jose Luis
    Cuddington, Clayton T.
    Wolfe, Savannah R.
    Palmer, Andre F.
    Cabrales, Pedro
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [8] Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock
    Cynthia R. Muller
    Alexander T. Williams
    Cynthia Walser
    Allyn M. Eaker
    Jose Luis Sandoval
    Clayton T. Cuddington
    Savannah R. Wolfe
    Andre F. Palmer
    Pedro Cabrales
    Scientific Reports, 12
  • [9] Preservation of Cardiac Structure and Function Compared to Brain in a Rat Hemorrhagic Shock Model
    Dai, Wangde
    Kloner, Robert A.
    CIRCULATION, 2016, 134
  • [10] Influence of Anesthetics on the Hemodynamic Response in a Rat Model of Hemorrhagic Shock
    Balzer, Claudius
    Baudenbacher, Franz J.
    Eagle, Susan S.
    Salzman, Michele M.
    Cleveland, William J.
    Riess, Matthias L.
    CIRCULATION, 2019, 140
12345