Effect of polymerized human placenta hemoglobin on hemodynamic parameter and cardiac function in a rat hemorrhagic shock model

被引：6
作者：
Li, Tao [2 ,3 ]
Jiang, Yongxian [2 ,3 ]
Zhang, Zhenyu [1 ]
Zhang, Sisi [2 ,3 ]
Wu, Wei [4 ]
Liao, Daqin [2 ,3 ]
Chen, Yanfang [2 ,3 ]
Yang, Chengmin [5 ]
Xu, Xuewen [1 ]
Liu, Jin [2 ,3 ]
机构：
[1] Sichuan Univ, W China Hosp, Dept Burn & Plast Surg, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Hosp, Translat Neurosci Ctr, Chengdu 610041, Peoples R China
[3] Sichuan Univ, W China Hosp, Lab Anesthesiol, Chengdu 610041, Peoples R China
[4] Chengdu Army Gen Hosp, Dept Anesthesiol, Chengdu, Peoples R China
[5] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
来源：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2012年 / 40卷 / 04期
关键词：
Hemoglobin-based oxygen carrier; hemorrhagic shock; resuscitation; cardiac function; ISCHEMIA-REPERFUSION INJURY; ORGAN DYSFUNCTION; OXYGEN CARRIERS; NITRIC-OXIDE; RESUSCITATION; VASOCONSTRICTION; HBOC-201;
D O I：
10.3109/10731199.2012.663384
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group. Therefore, our findings suggest that PolyPHb moderately improved hemodynamic recovery and provided little cardioprotective effect in hemorrhagic shock.
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收藏
页码：256 / 260
页数：5
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