Antiviral Triterpenoid Saponins from the Roots of Ilex asprella

被引:39
|
作者
Zhou, Min [1 ,2 ]
Xu, Min [1 ]
Ma, Xiao-Xia [1 ]
Zheng, Kai [3 ]
Yang, Ke [3 ]
Yang, Chong-Ren [1 ]
Wang, Yi-Fei [3 ]
Zhang, Ying-Jun [1 ]
机构
[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Heilongtan, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
[3] Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
关键词
Ilex asprella; Aquifoliaceae; sulfur-containing triterpenoid saponins; asprellanosides A and B; antiviral; IN-VITRO; GLYCOSIDES; LEAVES; PUBESCENS; EMBLICA; CORNUTA;
D O I
10.1055/s-0032-1315209
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3-12). An in vitro anti-HSV-1 activity test of the isolates (1-4, 6-7, and 9-12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.
引用
收藏
页码:1702 / 1705
页数:4
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