Synthesis and characterization of glycyrrhizin-decorated graphene oxide for hepatocyte-targeted delivery

被引：12

作者：

Wang, Zonghua ^{[1
]}

Gao, Yanli ^{[1
]}

Xia, Jianfei ^{[1
]}

Zhang, Feifei ^{[1
]}

Xia, Yanzhi ^{[1
]}

Li, Yanhui ^{[1
]}

机构：

[1] Qingdao Univ, Coll Chem & Environm Engn, Growing Base State Key Lab, Lab Fiber Mat & Modern Text, Qingdao 266071, Shandong, Peoples R China

来源：

COMPTES RENDUS CHIMIE | 2012年 / 15卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Glycyrrhizin; Graphene oxide; Hepatocyte-targeted; Drug delivery; CONTROLLED-RELEASE; CARBON NANOTUBES; RAT; REPLICATION; DOXORUBICIN; LIVER; ACID;

D O I：

10.1016/j.crci.2012.05.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The present work was to investigate graphene oxide (GO) decorated with glycyrrhizin (GL) which were conjugated via strong hydrogen-bonding interaction as a new hepatocyte-targeted delivery vehicle. The hydrogen-bonding interaction, simplified as a non-covalent type of functionalization, enables high drug loading and subsequent controlled release of the drug. An effective loading of GL on GO as high as 5.19 mg/mg was obtained at initial GL concentration of 0.6 mg/mL. The release of GL on GO showed strong pH dependence and the extent of release at pH 5.5 and 7.4 is 58.4% and 17.6% over 30 h in vitro respectively. The results show that the GO-GL complex seems to be a very promising vehicle for loading of drugs under neutral conditions and releasing under acidic environment. Furthermore. GO-GL can be obtained under mild conditions without addition of any organic solvents and surfactants, which is very suitable for pharmaceutical applications as a promising hepatocyte-targeted delivery carrier. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：708 / 713

页数：6

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