Increased Cortical Excitability with Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation in Adolescents with Treatment-Resistant Major Depressive Disorder

被引:20
|
作者
Croarkin, Paul E. [1 ]
Wall, Christopher A. [2 ]
Nakonezny, Paul A. [1 ]
Buyukdura, Jeylan S. [1 ]
Husain, Mustafa M. [1 ]
Sampson, Shirlene M. [2 ]
Emslie, Graham J. [1 ]
Kozel, Andrew [1 ]
机构
[1] UT SW Med Ctr Dallas, Div Child & Adolescent Psychiat, Dept Psychiat, Dallas, TX 75390 USA
[2] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA
关键词
MOTOR CORTEX EXCITABILITY; QUICK INVENTORY; RTMS; INHIBITION; CHILDREN; SCHIZOPHRENIA; THRESHOLD; THERAPY; TMS; SYMPTOMATOLOGY;
D O I
10.1089/cap.2011.0054
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To examine changes in motor cortical excitability in adolescent subjects receiving 30 sessions of high-frequency prefrontal repetitive transcranial magnetic stimulation (rTMS). Methods: Eight adolescents with treatment-resistant major depressive disorder (MDD) enrolled in an open augmentation trial of 10 Hz rTMS. Resting motor thresholds were obtained by the visualization of movement method with a maximum likelihood threshold hunting computer algorithm at baseline and after every five sessions of rTMS. Motor threshold was recorded as the percentage of total machine output at each measurement. Results: Motor threshold data from baseline, weeks 2, 4, and 5 were included in a mixed model repeated measure analysis to examine a change in least square mean effect over time. The omnibus effect did not reach statistical significance (F = 1.25, p = 0.32). However, multiple comparisons from the overall model demonstrated a decrease in the least square mean motor threshold. The mean contrast from baseline to week 5 approached significance (p = 0.07). Moreover, a post-hoc analysis with a Wilcoxon signed ranks test demonstrated a significant decrease at week 5 (p = 0.03). Conclusions: This suggests that high-frequency rTMS may increase cortical excitability in adolescents with treatment-resistant MDD.
引用
收藏
页码:56 / 64
页数:9
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