Catalyst Free Synthesis of Bis(Indolyl)Methanes and 3,3-Bis(Indolyl)oxindoles in Aqueous Ethyl Lactate

被引：29

作者：

Gao, Ge ^{[1
]}

Han, Yi ^{[1
]}

Zhang, Zhan-Hui ^{[1
]}

机构：

[1] Hebei Normal Univ, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Bis(indolyl)methanes; 3,3-Bis(indolyl)oxindoles; Ethyl lactate; Indoles; Ultrasound;

D O I：

10.1002/slct.201702326

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and environmentally friendly approach has been reported for the synthesis of bis(indolyl)methanes and 3,3-bis(indolyl)oxindoles by reacting of indoles with aldehydes or isatins in water-ethyl lactate under ultrasound irradiation. This protocol presents the benefits of catalyst-free, operational simplicity, short reaction time, high product yield, broad substrate scope and applicability for large-scale synthesis.

引用

页码：11561 / 11564

页数：4

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