Catalyst Free Synthesis of Bis(Indolyl)Methanes and 3,3-Bis(Indolyl)oxindoles in Aqueous Ethyl Lactate

被引：29

作者：

Gao, Ge ^{[1
]}

Han, Yi ^{[1
]}

Zhang, Zhan-Hui ^{[1
]}

机构：

[1] Hebei Normal Univ, Natl Demonstrat Ctr Expt Chem Educ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Bis(indolyl)methanes; 3,3-Bis(indolyl)oxindoles; Ethyl lactate; Indoles; Ultrasound;

D O I：

10.1002/slct.201702326

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and environmentally friendly approach has been reported for the synthesis of bis(indolyl)methanes and 3,3-bis(indolyl)oxindoles by reacting of indoles with aldehydes or isatins in water-ethyl lactate under ultrasound irradiation. This protocol presents the benefits of catalyst-free, operational simplicity, short reaction time, high product yield, broad substrate scope and applicability for large-scale synthesis.

引用

页码：11561 / 11564

页数：4

共 73 条

[1] A Catalyst-Free and Chemoselective Synthesis of Episulfides from Epoxides in 2,3-Butanediol without Formation of Poly(episulfide)s [J].

Aoyagi, Naoto ;

Endo, Takeshi .

CHEMISTRYSELECT, 2017, 2 (16) :4466-4468

[2] Selective Synthesis of Bis(indolyl)methanes Under Solvent Free Condition Using Glucopyranosylamine Derived cis-Dioxo Mo(VI) Complex as an Efficient Catalyst [J].

Baig, Noorullah ;

Shelke, Ganesh M. ;

Kumar, Anil ;

Sah, Ajay K. .

CATALYSIS LETTERS, 2016, 146 (02) :333-337

[3] Recent Developments on Ultrasound-Assisted Synthesis of Bioactive N-Heterocycles at Ambient Temperature [J].

Banerjee, Bubun .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2017, 70 (08) :872-888

[4] Recent developments on ultrasound assisted catalyst-free organic synthesis [J].

Banerjee, Bubun .

ULTRASONICS SONOCHEMISTRY, 2017, 35 :1-14

[5] Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles [J].

Banerjee, Bubun .

ULTRASONICS SONOCHEMISTRY, 2017, 35 :15-35

[6] Synthesis and evaluation of arylfuryl-bis(indolyl)methanes as selective chromogenic and fluorogenic ratiometric receptors for mercury ion in aqueous solution [J].

Batista, Rosa M. F. ;

Costa, Susana P. G. ;

Silva, Regina M. P. ;

Lima, Nuno E. M. ;

Raposo, M. Manuela M. .

DYES AND PIGMENTS, 2014, 102 :293-300

[7] A Facile, Catalyst-Free Mechano-Synthesis of Quinoxalines and their In-Vitro Antibacterial Activity Study [J].

Bhutia, Zigmee T. ;

Prasannakumar, Geethika ;

Das, Avijit ;

Biswas, Malabika ;

Chatterjee, Amrita ;

Banerjee, Mainak .

CHEMISTRYSELECT, 2017, 2 (03) :1183-1187

[8] Facile and Chemically Sustainable Catalyst-Free Synthesis of Diverse 2-Aryl-4-Alkyl/Aryl-Pyrano[3,2-c]chromen-5 (4H)-Ones by One-Pot Multicomponent Reactions at Room Temperature [J].

Brahmachari, Goutam ;

Nurjamal, Khondekar .

CHEMISTRYSELECT, 2017, 2 (13) :3695-3702

[9] Visible-Light-Induced C=C Bond Cleavage of Enaminones for the Synthesis of 1,2-Diketones and Quinoxalines in Sustainable Medium [J].

Cao, Shuo ;

Zhong, Shanshan ;

Xin, Luoting ;

Wan, Jie-Ping ;

Wen, Chengping .

CHEMCATCHEM, 2015, 7 (09) :1478-1482

[10] A green approach for synthesis of naphthoquinone-fused oxazine derivatives in water under ultrasonic irradiation [J].

Cao, Ya-Qian ;

Li, Xin-Ran ;

Wu, Wei ;

Zhang, Dan ;

Zhang, Zhan-Hui ;

Mo, Li-Ping .

RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (07) :3745-3755

← 1 2 3 4 5 6 7 8 →