Suppressing the growth of HL-60 acute myeloid leukemia cells by chitosan coated anthraquinone nanoparticles in vitro

被引：4
|
作者：
Alassaif, Fatimah Redah [1 ,2 ]
Alassaif, Eman Redah [3 ]
Chavali, Santosh Rani [4 ]
Dhanapal, Jeevitha [5 ]
机构：
[1] Prince Sultan Mil Med City, Dept Cent Mil Lab, Riyadh, Saudi Arabia
[2] Prince Sultan Mil Med City, Blood Bank, Riyadh, Saudi Arabia
[3] Almana Gen Hosp, Dept Clin Biochem, Dammam, Saudi Arabia
[4] Texas Tech Univ, Hlth Sci Ctr, Dept Pediat, Genet Lab, Lubbock, TX 79430 USA
[5] Labmate Asia Private Ltd, Biol Dept, Baid Mehta Complex 183,Mt Rd, Chennai 600015, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 14期
关键词：
Acute myeloid leukemia; anthraquinone; chitosan; DNA fragmentation; flow cytometry; ALGINATE GEL BEADS; DRUG-DELIVERY; CYTOCHROME-C; RELEASE; CANCER; DNA; DOXORUBICIN; APOPTOSIS; ANTHRACYCLINES; CHECKPOINT;
D O I：
10.1080/00914037.2018.1509340
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The aim of this work was to formulate Anthraquinone (AQ) loaded Chitosan (CS) nanoparticles using ionic gelation technique. The shape and size of the nanoparticles was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta sizer and zeta potential. The drug release was studied and confirmed the sustained release of the drug. The cytotoxic effects were tested in-vitro against acute myeloid leukemia (HL-60) cells. Apoptosis investigations including cellular uptake, DNA fragmentation, and flow cytometry evaluation of the chitosan-anthraquinone nanoparticles was conducted. These results conclude that CS-AQ NPs have the ability to act against HL-60 cells.
引用
收藏
页码：819 / 826
页数：8
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