Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

被引：12
作者：
Attia, Mohamed I. [1 ,2 ]
Aboul-Enein, Mohamed N. [2 ]
El-Azzouny, Aida A. [2 ]
Maklad, Yousreya A. [3 ]
Ghabbour, Hazem A. [1 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Med Chem Grp, Med & Pharmaceut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
[3] Natl Res Ctr, Pharmacol Grp, Med & Pharmaceut Chem Dept, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt
来源：
SCIENTIFIC WORLD JOURNAL | 2014年
关键词：
ANTI-CONVULSANT DRUG; ANTIEPILEPTIC DRUGS; DENZIMOL; SEMICARBAZONES; EPILEPSY; DESIGN;
D O I：
10.1155/2014/357403
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 mu mol/kg in the scPTZ screen without any neurotoxicity. The assigned ( E)-configuration of the title compounds 6a-p was confirmed via single crystal X-ray structure of compound 6g.
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页数：9
相关论文
共 24 条
[1]   Design and synthesis of novel stiripentol analogues as potential anticonvulsants [J].
Aboul-Enein, Mohamed N. ;
El-Azzouny, Aida A. ;
Attia, Mohamed I. ;
Maklad, Yousreya A. ;
Amin, Kamilia M. ;
Abdel-Rehim, Mohamed ;
El-Behairy, Mohammed F. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 47 :360-369
[2]   Synthesis and Anti-Candida Potential of Certain Novel 1-[(3-Substituted-3-phenyl)propyl]-1H-imidazoles [J].
Aboul-Enein, Mohamed Nabil ;
El-Azzouny, Aida Abd El-Sattar ;
Attia, Mohamed Ibrahim ;
Saleh, Ola Ahmed ;
Kansoh, Amany Lotfy .
ARCHIV DER PHARMAZIE, 2011, 344 (12) :794-801
[3]   Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives [J].
Alam, Ozair ;
Mullick, Pooja ;
Verma, S. P. ;
Gilani, Sadaf J. ;
Khan, Suroor A. ;
Siddiqui, Nadeem ;
Ahsan, Waquar .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (06) :2467-2472
[4]  
ATTIA MI, 2013, J CHEM-NY, DOI DOI 10.1155/2013/515309
[5]   1-{(E)-[3-(1H-Imidazol-1-yl)-1-phenylpropylidene]amino}-3-(2-methylphenyl)urea [J].
Attia, Mohamed I. ;
Aboul-Enein, Mohamed N. ;
El-Brollosy, Nasser R. ;
Ng, Seik Weng ;
Tiekink, Edward R. T. .
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 :O1848-+
[6]   1-{(E)-[3-(1H-Imidazol-1-yl)-1-(4-methoxyphenyl) propylidene] amino}-3-(2-methylphenyl) urea [J].
Attia, Mohamed I. ;
Aboul-Enein, Mohamed N. ;
El-Brollosy, Nasser R. ;
Ng, Seik Weng ;
Tiekin, Edward R. T. .
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 :O1799-+
[7]   Primary care: Epilepsy. [J].
Browne, TR ;
Holmes, GL .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (15) :1145-1151
[8]   EVALUATION OF THE SEMICARBAZONES, THIOSEMICARBAZONES AND BIS-CARBOHYDRAZONES OF SOME ARYL ALICYCLIC KETONES FOR ANTICONVULSANT AND OTHER BIOLOGICAL PROPERTIES [J].
DIMMOCK, JR ;
PANDEYA, SN ;
QUAIL, JW ;
PUGAZHENTHI, U ;
ALLEN, TM ;
KAO, GY ;
BALZARINI, J ;
DECLERCQ, E .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1995, 30 (04) :303-314
[9]   Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds [J].
Dimmock, JR ;
Vashishtha, SC ;
Stables, JP .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (02) :241-248
[10]   A NOTE ON A SIMPLE APPARATUS FOR DETECTING NEUROLOGICAL DEFICIT IN RATS AND MICE [J].
DUNHAM, NW ;
MIYA, TS .
JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1957, 46 (03) :208-209
123