Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group

被引:562
作者
Tuck, Melissa K. [1 ]
Chan, Daniel W. [2 ]
Chia, David [3 ]
Godwin, Andrew K. [4 ]
Grizzle, William E. [5 ]
Krueger, Karl E. [6 ]
Rom, William [7 ]
Sanda, Martin [8 ]
Sorbara, Lynn [6 ]
Stass, Sanford [9 ]
Wang, Wendy [6 ]
Brenner, Dean E. [1 ]
机构
[1] Univ Michigan, Canc & Geriatr Ctr 2150, Div Hematol Oncol, Ann Arbor, MI 48109 USA
[2] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21231 USA
[3] Univ Calif Los Angeles, Immunogenet Ctr, Los Angeles, CA 90095 USA
[4] Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA 19111 USA
[5] Univ Alabama, Birmingham, AL 35233 USA
[6] NCI, Canc Biomarkers Res Grp, Canc Prevent Div, NIH, Bethesda, MD 20892 USA
[7] NYU, Sch Med, New York, NY 10016 USA
[8] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[9] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA
关键词
Consensus; Serum collection; Plasma collection; Standard Operating Procedures; Biomarkers; Sample handling;
D O I
10.1021/pr800545q
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Specimen collection is an integral component of clinical research. Specimens from subjects with various stages of cancers or other conditions, as well as those without disease, are critical tools in the hunt for biomarkers, predictors, or tests that will detect serious diseases earlier or more readily than currently possible. Analytic methodologies evolve quickly. Access to high-quality specimens, collected and handled in standardized ways that minimize potential bias or confounding factors, is key to the "bench to bedside" aim of translational research. It is essential that standard operating procedures, "the how" of creating the repositories, be defined prospectively when designing clinical trials. Small differences in the processing or handling of a specimen can have dramatic effects in analytical reliability and reproducibility, especially when multiplex methods are used. A representative working group, Standard Operating Procedures Internal Working Group (SOPIWG), comprised of members from across Early Detection Research Network (EDRN) was formed to develop standard operating procedures (SOPs) for various types of specimens collected and managed for our biomarker discovery and validation work. This report presents our consensus on SOPs for the collection, processing, handling, and storage of serum and plasma for biomarker discovery and validation.
引用
收藏
页码:113 / 117
页数:5
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