PrEP Nonadherence, White Coat Dosing, and HIV Risk Among a Cohort of MSM

被引：5
作者：
Blair, Cherie S. [1 ]
Boymer, Matthew R. [2 ]
Kofron, Ryan M. [3 ]
Bolan, Robert K. [4 ]
Jordan, Wilbert C. [5 ]
Haubrick, Richani H. [6 ]
Wohl, Amy R. [7 ]
Landovitz, Raphael J. [1 ,3 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Infect Dis, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Fielding Sch Publ & Lealth, Dept Community Hlth Sci, Los Angeles, CA 90095 USA
[3] UCLA Ctr Clin AIDS Res & Educ, Los Angeles, CA USA
[4] Los Angeles & GBT Ctr, Dept Hlth & Mental Hlth Serv, Los Angeles, CA USA
[5] Charles R Drew Univ Med & Sci, OASIS Clin, 1621 E 120th St, Los Angeles, CA 90059 USA
[6] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA
[7] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 08期
基金：
美国国家卫生研究院;
关键词：
MSM; pm-exposure prophylaxis; PrEP adherence; syphilis; white coat dosing; DRIED BLOOD SPOTS; PREEXPOSURE PROPHYLAXIS; ADHERENCE; TENOFOVIR; EMTRICITABINE; MEN; SEX;
D O I：
10.1093/ofid/ofaa329
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the need for identifying and reducing barriers to PrEP adherence.
引用
收藏
页数：4
相关论文
共 25 条
[1]   What Can Urine Tell Us About Medication Adherence? [J].
Anderson, Peter L. .
ECLINICALMEDICINE, 2018, 2-3 :5-6
[2]   Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men [J].
Anderson, Peter L. ;
Glidden, David V. ;
Liu, Albert ;
Buchbinder, Susan ;
Lama, Javier R. ;
Vicente Guanira, Juan ;
McMahan, Vanessa ;
Bushman, Lane R. ;
Casapia, Martin ;
Montoya-Herrera, Orlando ;
Veloso, Valdilea G. ;
Mayer, Kenneth H. ;
Chariyalertsak, Suwat ;
Schechter, Mauro ;
Bekker, Linda-Gail ;
Kallas, Esper Georges ;
Grant, Robert M. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (151)
[3]   Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing [J].
Castillo-Mancilla, Jose ;
Seifert, Sharon ;
Campbell, Kayla ;
Coleman, Stacey ;
McAllister, Kevin ;
Zheng, Jia-Hua ;
Gardner, Edward M. ;
Liu, Albert ;
Glidden, David V. ;
Grant, Robert ;
Hosek, Sybil ;
Wilson, Cralg M. ;
Bushman, Lane R. ;
MaWhinney, Samantha ;
Anderson, Peter L. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (11) :6692-6697
[4]   Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring [J].
Castillo-Mancilla, Jose R. ;
Haberer, Jessica E. .
CURRENT HIV/AIDS REPORTS, 2018, 15 (01) :49-59
[5]  
Castillo-Mancilla JR, 2013, AIDS RES HUM RETROV, V29, P384, DOI [10.1089/aid.2012.0089, 10.1089/AID.2012.0089]
[6]   FEM-PrEP: Adherence Patterns and Factors Associated With Adherence to a Daily Oral Study Product for Pre-exposure Prophylaxis [J].
Corneli, Amy L. ;
Deese, Jennifer ;
Wang, Meng ;
Taylor, Doug ;
Ahmed, Khatija ;
Agot, Kawango ;
Lombaard, Johan ;
Manongi, Rachel ;
Kapiga, Saidi ;
Kashuba, Angela ;
Van Damme, Lut .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 66 (03) :324-331
[7]   Reported Cases of Neurosyphilis Among Early Syphilis CasesUnited States, 2009 to 2015 [J].
de Voux, Alex ;
Kidd, Sarah ;
Torrone, Elizabeth A. .
SEXUALLY TRANSMITTED DISEASES, 2018, 45 (01) :39-41
[8]  
Driscoll Kimberly A, 2017, J Diabetes Sci Technol, V11, P455, DOI 10.1177/1932296816672691
[9]   ON WHITE-COAT EFFECTS AND THE ELECTRONIC MONITORING OF COMPLIANCE [J].
FEINSTEIN, AR .
ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (07) :1377-1378
[10]   Validation of a Urine Tenofovir Immunoassay for Adherence Monitoring to PrEP and ART and Establishing the Cutoff for a Point-of-Care Test [J].
Gandhi, Monica ;
Bacchetti, Peter ;
Spinelli, Matthew A. ;
Okochi, Hideaki ;
Baeten, Jared M. ;
Siriprakaisil, Oraphan ;
Klinbuayaem, Virat ;
Rodrigues, Warren C. ;
Wang, Guohong ;
Vincent, Michael ;
Cressey, Tim R. ;
Drain, Paul K. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2019, 81 (01) :72-77
123