Neural regulation of immunity: molecular mechanisms and clinical translation

被引：356

作者：

Pavlov, Valentin A. ^{[1
,2
]}

Tracey, Kevin J. ^{[1
,2
]}

机构：

[1] Northwell Hlth, Feinstein Inst Med Res, Ctr Biomed Sci, Manhasset, NY USA

[2] Northwell Hlth, Feinstein Inst Med Res, Ctr Bioelect Med, Manhasset, NY USA

来源：

NATURE NEUROSCIENCE | 2017年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

VAGUS NERVE-STIMULATION; SPINAL-CORD-INJURY; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; SYSTEMIC INFLAMMATORY RESPONSE; IMPROVES SURVIVAL; T-CELLS; LETHAL ENDOTOXEMIA; BRAIN-STIMULATION; SENSORY NEURONS; ACTIVATION;

D O I：

10.1038/nn.4477

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.

引用

页码：156 / 166

页数：11

共 148 条

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