Epinardins A-D, new pyrroloiminoquinone alkaloids of undetermined deep-water green demosponges from pre-antarctic Indian ocean

被引：36

作者：

DAmbrosio, M ^{[1
]}

Guerriero, A ^{[1
]}

Chiasera, G ^{[1
]}

Pietra, F ^{[1
]}

机构：

[1] PHARMACIA UPJOHN,I-20014 MILAN,ITALY

来源：

TETRAHEDRON | 1996年 / 52卷 / 26期

关键词：

D O I：

10.1016/0040-4020(96)00438-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel pyrroloiminoquinone alkaloids that differ from members of the discorhabdin/prianosin family for having an allylic alcohol functionality in place of the enone system, epinardins A-D (8-11), have been isolated from undetermined deep-water green demosponges collected in pre-Antarctic waters near the Crozet Islands. Relative stereochemistry has been fully assigned from high-field NMR spectra. Epinardin C (10) proved strongly cytotoxic towards doxorubicin-resistant L1210/DX tumoural cells in vitro. (C) 1996 Elsevier Science Ltd

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页码：8899 / 8906

页数：8

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