Chiral ligand-exchange chromatography for separation of three stereoisomers of octahydroindole-2-carboxylic acid

被引：11
|
作者：
Sun, SY
Jia, YZ
Zeng, N
Li, FM [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
[2] Shanghai Inst Pharmaceut Ind, Shanghai 200437, Peoples R China
来源：
CHROMATOGRAPHIA | 2006年 / 63卷 / 7-8期
关键词：
column liquid chromatography; diastereo-enantio separation; chiral mobile phase; ligand-exchange; octohydroindole-2-carboxylic acid;
D O I：
10.1365/s10337-006-0752-7
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel HPLC method is described for separation of the three stereoisomers of octahydroinclole-2-carboxylic acid (Oic), an intermediate in the synthesis of perindopril. The chiral mobile phase contained the complex of Cu(II) with the optically active selector L-phenylalaninamide (L-PheA), and an ion-pair reagent, sodium 1-octanesulfonate. The effects of the concentrations of the Cu(II)-L-PheA complex and the ion-pair reagent, mobile phase pH, ionic strength, acetonitrile content, and column temperature were studied. Satisfactory resolution was achieved for three stereoisomers, RRR-, SSS-, and SRR-Oic.
引用
收藏
页码：331 / 335
页数：5
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