Epigenetics, DNA Methylation and Chromatin Modifying Drugs

被引：255
作者：
Szyf, Moshe [1 ]
机构：
[1] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H3G 1Y6, Canada
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2009年 / 49卷
关键词：
DNA methylation; chromatin structure; histone deacetylase inhibitors; methyltransferase; demethylase; epigenetics; HISTONE DEACETYLASE INHIBITOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CANCER-CELL-LINES; SMALL-MOLECULE INHIBITOR; ADENOSYL-L-METHIONINE; GENE-EXPRESSION; T-CELLS; CPG METHYLATION; TRICHOSTATIN-A; SILENCED GENES;
D O I：
10.1146/annurev-pharmtox-061008-103102
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Evidence is emerging that several diseases and behavioral pathologies result from defects in gene function. The best-studied example is cancer, but other diseases such as autoimmune disease, asthma, type 2 diabetes, metabolic disorders, and autism display aberrant gene expression. Gene function may be altered by either a change in the sequence of the DNA or a change in epigenetic programming of a gene in the absence of a sequence change. With epigenetic drugs, it is possible to reverse aberrant gene expression profiles associated with different disease states. Several epigenetic drugs targeting DNA methylation and historic deacetylation enzymes have been tested in clinical trials. Understanding the epigenetic machinery and the differential roles of its components in specific disease states is essential for developing targeted epigenetic therapy.
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收藏
页码：243 / 263
页数：21
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