Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice

被引：33
作者：
Chen, Lukui [1 ]
Miao, Wei [1 ]
Tang, Xiaoyong [2 ]
Zhang, Haipeng [3 ]
Wang, Shengyu [4 ]
Luo, Fanghong [4 ]
Yan, Jianghua [4 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Dept Neurosurg, Nanjing 210009, Jiangsu, Peoples R China
[2] Fourth Hosp Chongqing, Dept Neurosurg, Chongqing 404000, Peoples R China
[3] Xiamen Univ, Coll Med, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Canc Res Ctr, Xiamen 361005, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2013年 / 9卷 / 04期
关键词：
Neuropilin-1; Monoclonal Antibody; Glioma Tumor; Inhibitory Effect; DUAL-COLOR HYBRIDIZATION; MAGNETIC NANOPARTICLES ARRAY; ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; SINGLE-BASE EXTENSION; EXPRESSION; RECEPTOR; CANCER; FABRICATION; VEGF(165);
D O I：
10.1166/jbn.2013.1623
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This article reports the effect of Neuropilin-1 monoclonal antibody (NRP-1 MAb) on glioma cell lines in vitro and the effect on nude mice bearing glioma tumor (U87) in vivo. MTT, the scratch test and transwell test were used to evaluate the inhibitory effect of NRP-1 MAb on glioma cell lines. The tissue distribution and tumor targeting capability of NRP-1 MAb in U87 Xenografts nude mice was determined in Optical Imaging. Anti-glioma experiment was carried out by NRP-1 MAb on U87 Xenografts nude mice. NRP-1 MAb was showed to inhibit the proliferation, migration and invasion of glioma cells. NRP-1 MAb can specifically target the tumor in U87 Xenografts nude mice and reduce the proliferation activity of the tumor. The results of this study indicate that NRP-1 MAb can inhibit the proliferation, migration and metastasis of glioma cell lines and can target the glioma tumor to reduce tumor growth. Therefore, NRP-1 MAb may be an effective agent for glioma-targeted therapy.
引用
收藏
页码：551 / 558
页数：8
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