Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy

被引：6

作者：

Yu, Xiaofei

Wang, Xiang-Yang ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA 23220 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 05期

关键词：

innate immune receptor; dendritic cells; CD204; vaccine; T-cell response; tumor immunity; ANTITUMOR IMMUNITY; ACTIVATION;

D O I：

10.4161/onci.19728

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represents a promising approach to the improvement of cancer immunotherapy.

引用

页码：770 / 772

页数：3

共 15 条

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