Optimized temporal pattern of brain stimulation designed by computational evolution

被引：104
作者：
Brocker, David T. [1 ]
Swan, Brandon D. [1 ]
So, Rosa Q. [1 ]
Turner, Dennis A. [2 ,3 ]
Gross, Robert E. [4 ,5 ,6 ]
Grill, Warren M. [1 ,2 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Neurosurg, Durham, NC 27710 USA
[4] Emory Univ, Dept Neurosurg, Atlanta, GA 30322 USA
[5] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA
[6] Georgia Inst Technol, Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2017年 / 9卷 / 371期
关键词：
SUBTHALAMIC NUCLEUS STIMULATION; DISEASE RATING-SCALE; PARKINSONS-DISEASE; OSCILLATORY SYNCHRONIZATION; NEURONAL-ACTIVITY; GENERATOR REPLACEMENT; PALLIDAL STIMULATION; TREMOR AMPLITUDE; BASAL GANGLIA; BRADYKINESIA;
D O I：
10.1126/scitranslmed.aah3532
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brain stimulation is a promising therapy for several neurological disorders, including Parkinson's disease. Stimulation parameters are selected empirically and are limited to the frequency and intensity of stimulation. We varied the temporal pattern of deep brain stimulation to ameliorate symptoms in a parkinsonian animal model and in humans with Parkinson's disease. We used model-based computational evolution to optimize the stimulation pattern. The optimized pattern produced symptom relief comparable to that from standard high-frequency stimulation (a constant rate of 130 or 185 Hz) and outperformed frequency-matched standard stimulation in a parkinsonian rat model and in patients. Both optimized and standard high-frequency stimulation suppressed abnormal oscillatory activity in the basal ganglia of rats and humans. The results illustrate the utility of model-based computational evolution of temporal patterns to increase the efficiency of brain stimulation in treating Parkinson's disease and thereby reduce the energy required for successful treatment below that of current brain stimulation paradigms.
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页数：11
相关论文
共 76 条
[1]  
[Anonymous], 1991, Handbook of Genetic Algorithms
[2]   Pallidal stimulation: Effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease [J].
Baker, Kenneth B. ;
Zhang, Jianyu ;
Vitek, Jerrold L. .
EXPERIMENTAL NEUROLOGY, 2011, 231 (02) :309-313
[3]  
BENABID AL, 1994, STEREOT FUNCT NEUROS, V62, P76, DOI 10.1159/000098600
[4]   Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease [J].
Benabid, Alim Louis ;
Chabardes, Stephan ;
Mitrofanis, John ;
Pollak, Pierre .
LANCET NEUROLOGY, 2009, 8 (01) :67-81
[5]   THE PRIMATE SUBTHALAMIC NUCLEUS .2. NEURONAL-ACTIVITY IN THE MPTP MODEL OF PARKINSONISM [J].
BERGMAN, H ;
WICHMANN, T ;
KARMON, B ;
DELONG, MR .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (02) :507-520
[6]   Modulation of tremor amplitude during deep brain stimulation at different frequencies [J].
Beuter, A ;
Titcombe, MS .
BRAIN AND COGNITION, 2003, 53 (02) :190-192
[7]   Longevity of batteries in internal pulse generators used for deep brain stimulation [J].
Bin-Mahfoodh, M ;
Hamani, C ;
Sime, E ;
Lozano, AM .
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 2003, 80 (1-4) :56-60
[8]   Tremor varies as a function of the temporal regularity of deep brain stimulation [J].
Birdno, Merrill J. ;
Kuncel, Alexis M. ;
Dorval, Alan D. ;
Turner, Dennis A. ;
Grill, Warren M. .
NEUROREPORT, 2008, 19 (05) :599-602
[9]   Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation [J].
Birdno, Merrill J. ;
Kuncel, Alexis M. ;
Dorval, Alan D. ;
Turner, Dennis A. ;
Gross, Robert E. ;
Grill, Warren M. .
JOURNAL OF NEUROPHYSIOLOGY, 2012, 107 (01) :364-383
[10]   Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease [J].
Brocker, David T. ;
Swan, Brandon D. ;
Turner, Dennis A. ;
Gross, Robert E. ;
Tatter, Stephen B. ;
Koop, Mandy Miller ;
Bronte-Stewart, Helen ;
Grill, Warren M. .
EXPERIMENTAL NEUROLOGY, 2013, 239 :60-67
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