Quality of life in adults with Gilles de la Tourette Syndrome

被引:50
作者
Jalenques, Isabelle [1 ,2 ]
Galland, Fabienne [1 ]
Malet, Laurent [3 ]
Morand, Dominique
Legrand, Guillaume [1 ,2 ]
Auclair, Candy
Hartmann, Andreas [4 ]
Derost, Philippe [2 ]
Durif, Franck [2 ]
机构
[1] CHU Clermont Ferrand, Serv Psychiat Adulte & Psychol Med A, Hop Gabriel Montpied, F-63003 Clermont Ferrand, France
[2] Univ Clermont 1, Clermont Univ, UFR Med, EA 3845, F-63001 Clermont Ferrand, France
[3] CHU Clermont Ferrand, Serv Psychiat Adulte B, Hop Gabriel Montpied, F-63003 Clermont Ferrand, France
[4] Grp Hosp Pitie Salpetriere, Dept Neurol, Ctr Reference Syndrome Gilles Tourette, F-75013 Paris, France
来源
BMC PSYCHIATRY | 2012年 / 12卷
关键词
Gilles de la Tourette Syndrome; Quality of life; Physical and psychological health status; Psychology; Psychiatric disorders; Depression; VALIDITY; QUESTIONNAIRE; YOUTH; QOL;
D O I
10.1186/1471-244X-12-109
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Few studies have used standardized QOL instruments to assess the quality of life (QOL) in Gilles de la Tourette Syndrome (GTS) patients. This work investigates the QOL of adult GTS patients and examines the relationships between physical and psychological variables and QOL. Methods: Epidemiological investigation by anonymous national postal survey of QOL of patients of the French Association of Gilles de la Tourette Syndrome (AFGTS) aged 16 years or older. The clinical and QOL measures were collected by four questionnaires: a sociodemographic and GTS-related symptoms questionnaire, the World Health Organization Quality Of Life questionnaire (WHOQOL-26), the Functional Status Questionnaire (FSQ), and a self-rating questionnaire on psychiatric symptoms (SCL-90), all validated in French. We used stepwise regression analysis to explicitly investigate the relationships between physical and psychological variables and QOL domains in GTS. Results: Questionnaires were posted to 303 patients, of whom 167 (55%) completed and returned them. Our results, adjusted for age and gender, show that patients with GTS have a worse QOL than the general healthy population. In particular, the "Depression" psychological variable was a significant predictor of impairment in all WHOQOL-26 domains, psychological but also physical and social. Conclusions: The present study demonstrates a strong relationship between QOL in GTS and psychiatric symptoms, in particular those of depression.
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页数:9
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