Free radicals and disease

被引：300
作者：
Moskovitz, J [1 ]
Yim, MB [1 ]
Chock, PB [1 ]
机构：
[1] NHLBI, Biochem Lab, NIH, Bethesda, MD 20892 USA
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2002年 / 397卷 / 02期
关键词：
D O I：
10.1006/abbi.2001.2692
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Free radicals and reactive oxygen species (ROS) have been associated with the etiology and/or progression of a number of diseases and in aging. Many of the proteins oxidatively modified by free radicals contain side-chain carbonyl derivatives, which can be used as markers for protein oxidation. The protein carbonyl content has been quantitated as a function of age for human cultured dermal fibroblasts, lens, and brain tissue. These data were analyzed using a simple autocatalytic model with the assumption that free radicals randomly oxidize proteins or peptides to form carbonyl derivatives and lead to their inactivation. The carbonylated proteins and peptides are highly susceptible to proteolytic degradation. Implication of free radicals in aging and in age-dependent susceptibility to neurodegenerative diseases will be discussed in light of this simplified kinetic model. (C) 2002 Elsevier Science.
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收藏
页码：354 / 359
页数：6
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