机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Azofeifa, Joseph G.
[1
,2
]
Allen, Mary A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Allen, Mary A.
[2
]
Hendrix, Josephina R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Hendrix, Josephina R.
[1
,3
]
Read, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
Univ Colorado, Dept Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Read, Timothy
[2
,4
]
Rubin, Jonathan D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Biochem, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Rubin, Jonathan D.
[4
]
Dowell, Robin D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Colorado, Dept Comp Sci, Boulder, CO 80309 USA
Dowell, Robin D.
[1
,2
,3
]
机构:
[1] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA
[2] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
[3] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
[4] Univ Colorado, Dept Biochem, Boulder, CO 80309 USA
Transcription factors (TFs) exert their regulatory influence through the binding of enhancers, resulting in coordination of gene expression programs. Active enhancers are often characterized by the presence of short, unstable transcripts termed enhancer RNAs (eRNAs). While their function remains unclear, we demonstrate that eRNAs are a powerful readout of TF activity. We infer sites of eRNA origination across hundreds of publicly available nascent transcription data sets and show that eRNAs initiate from sites of TF binding. By quantifying the colocalization of TF binding motif instances and eRNA origins, we derive a simple statistic capable of inferring TF activity. In doing so, we uncover dozens of previously unexplored links between diverse stimuli and the TFs they affect.
机构:
Univ Edinburgh, Med Res Council Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, ScotlandUniv Lausanne, Dept Computat Biol, Lausanne, Switzerland
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH USACase Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Nojima, Masanori
Huang, Yehong
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH USACase Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Huang, Yehong
Tyagi, Mudit
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH USACase Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Tyagi, Mudit
Kao, Hung-Ying
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH USACase Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Kao, Hung-Ying
Fujinaga, Koh
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH USACase Western Reserve Univ, Sch Med, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, EnglandUniv London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England
Wiesler, Simone C.
Weinzierl, Robert O. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Mol Biosci, London SW7 2AZ, EnglandUniv London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England
Weinzierl, Robert O. J.
Buck, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, EnglandUniv London Imperial Coll Sci Technol & Med, Dept Life Sci, Div Cell & Mol Biol, London SW7 2AZ, England
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Meers, Michael P.
Adelman, Karen
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Adelman, Karen
Duronio, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Duronio, Robert J.
Strahl, Brian D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Strahl, Brian D.
McKay, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
McKay, Daniel J.
Matera, A. Gregory
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USAUniv N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA
机构:
NIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USANIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Kim, Juhyun
Diaz, Luis F.
论文数: 0引用数: 0
h-index: 0
机构:
NIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Oregon Hlth & Sci Univ, Portland, OR 97239 USANIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Diaz, Luis F.
Miller, Matthew J.
论文数: 0引用数: 0
h-index: 0
机构:
NIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Univ Iowa, Med Sch, Iowa City, IA 52242 USANIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Miller, Matthew J.
Leadem, Benjamin
论文数: 0引用数: 0
h-index: 0
机构:
NIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
GeneDx, Gaithersburg, MD 20877 USANIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Leadem, Benjamin
Krivega, Ivan
论文数: 0引用数: 0
h-index: 0
机构:
NIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA
Sonothera, South San Francisco, CA 94080 USANIDDKD, Lab Cellular & Dev Biol, NIH, Bethesda, MD 20892 USA