The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes

被引：27

作者：

Ryba-Stanislawowska, Monika ^{[1
]}

Skrzypkowska, Maria ^{[1
]}

Mysliwska, Jolanta ^{[1
]}

Mysliwiec, Malgorzata ^{[2
]}

机构：

[1] Med Univ Gdansk, Dept Immunol, PL-80210 Gdansk, Poland

[2] Med Univ Gdansk, Pediat Clin, Dept Diabetol & Endocrinol, PL-80210 Gdansk, Poland

来源：

MEDIATORS OF INFLAMMATION | 2013年 / 2013卷

关键词：

REGULATORY T-CELLS; TH17; CELLS; INTERLEUKIN-6; CHILDREN; INFLAMMATION; EXPRESSION; IMBALANCE; NEPHROPATHY; CYTOKINE; PATHWAY;

D O I：

10.1155/2013/205284

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.

引用

页数：7

共 40 条

[1] Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New [J].

Alunno, Alessia ;

Bartoloni, Elena ;

Bistoni, Onelia ;

Nocentini, Giuseppe ;

Ronchetti, Simona ;

Caterbi, Sara ;

Valentini, Valentina ;

Riccardi, Carlo ;

Gerli, Roberto .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012,

[2] Diagnosis and classification of diabetes mellitus [J].

DIABETES CARE, 2008, 31 :S55-S60

[3]

[Anonymous], CLIN IMMUNOLOGY PRIN

[4] Regulatory T cells and inhibitory cytokines in autoimmunity [J].

Bettini, Maria ;

Vignali, Dario A. A. .

CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (06) :612-618

[5] The Th17/Treg imbalance in patients with acute coronary syndrome [J].

Cheng, Xiang ;

Yu, Xian ;

Ding, Ying-jun ;

Fu, Qing-qing ;

Xie, Jiang-jiao ;

Tang, Ting-ting ;

Yao, Rui ;

Chen, Yong ;

Liao, Yu-hua .

CLINICAL IMMUNOLOGY, 2008, 127 (01) :89-97

[6]

Cheung CMG, 2012, MOL VIS, V18, P830

[7] Human regulatory T cells and autoimmunity [J].

Costantino, Cristina M. ;

Baecher-Allan, Clare M. ;

Hafler, David A. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (04) :921-924

[8] Serum IL-1β, IL-2, and IL-6 in insulin-dependent diabetic children [J].

Dogan, Yasar ;

Akarsu, Saadet ;

Ustundag, Bilal ;

Yilmaz, Erdal ;

Gurgoze, Metin Kaya .

MEDIATORS OF INFLAMMATION, 2006, 2006

[9] Cutting edge:: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+ CD25- T cells [J].

Dominitzki, Sabine ;

Fantini, Massimo C. ;

Neufert, Clemens ;

Nikolaev, Alexei ;

Galle, Peter R. ;

Scheller, Juergen ;

Monteleone, Giovanni ;

Rose-John, Stefan ;

Neurath, Markus F. ;

Becker, Christoph .

JOURNAL OF IMMUNOLOGY, 2007, 179 (04) :2041-2045

[10] Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes [J].

Ferraro, Alessandra ;

Socci, Carlo ;

Stabilini, Angela ;

Valle, Andrea ;

Monti, Paolo ;

Piemonti, Lorenzo ;

Nano, Rita ;

Olek, Sven ;

Maffi, Paola ;

Scavini, Marina ;

Secchi, Antonio ;

Staudacher, Carlo ;

Bonifacio, Ezio ;

Battaglia, Manuela .

DIABETES, 2011, 60 (11) :2903-2913

← 1 2 3 4 →