Immobilization of DNA-Au nanoparticles on aminosilane-functionalized aluminum nitride epitaxial films for surface acoustic wave sensing

被引：12
作者：
Chiu, Chi-Shun [1 ]
Lee, Hong-Mao [2 ]
Kuo, Cheng-Tai [2 ]
Gwo, Shangjr [1 ,2 ]
机构：
[1] Natl Tsing Hua Univ, Inst Nanoengn & Microsyst, Hsinchu 30013, Taiwan
[2] Natl Tsing Hua Univ, Dept Phys, Hsinchu 30013, Taiwan
来源：
APPLIED PHYSICS LETTERS | 2008年 / 93卷 / 16期
关键词：
D O I：
10.1063/1.3003875
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
A generic method for immobilization of gold nanoparticle bioconjugates onto aluminum nitride (AlN) surfaces using aminosilane molecules as cross-linkers is demonstrated for surface acoustic wave (SAW) sensor applications. Electrostatic interaction between positively charged surface amine groups and negatively charged DNA-Au nanoparticle conjugates allows the self-assembly of a probe nanoparticle monolayer onto functionalized AlN surfaces under physiological conditions. Both 10 and 20 nm Au nanoparticles bound with thiolated oligonucleotides were employed in the detection scheme. We show that Au nanoparticles can play multiple roles in SAW sensing for probe immobilization, signal amplification, and labeling. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.3003875].
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页数：3
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