Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457

被引：80

作者：

Wang, Fa-Zuo ^{[1
]}

Huang, Zhi ^{[1
]}

Shi, Xue-Feng ^{[1
]}

Chen, Yu-Chan ^{[2
]}

Zhang, Wei-Min ^{[2
]}

Tian, Xin-Peng ^{[1
]}

Li, Jie ^{[1
]}

Zhang, Si ^{[1
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China

[2] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 23期

基金：

国家高技术研究发展计划(863计划);

关键词：

Indole diketopiperazine; Cytotoxicity; Acrostalagmus luteoalbus; Marine fungi; Deep-sea sediment; MARINE NATURAL-PRODUCTS; GLIOCLADIUM-ROSEUM; DRUG LEADS; DERIVATIVES; ALKALOIDS;

D O I：

10.1016/j.bmcl.2012.08.115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. (C) 2012 Published by Elsevier Ltd.

引用

页码：7265 / 7267

页数：3

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