Pathogenic Pore-Forming Proteins: Function and Host Response

被引：150

作者：

Bischofberger, Mirko ^{[1
]}

Iacovache, Ioan ^{[1
]}

van der Goot, F. Gisou ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

来源：

CELL HOST & MICROBE | 2012年 / 12卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

PLASMA-MEMBRANE-REPAIR; AUREUS ALPHA-TOXIN; CHOLESTEROL-DEPENDENT CYTOLYSIN; NF-KAPPA-B; LISTERIOLYSIN-O; CASPASE-1; ACTIVATION; CELL-DEATH; NLRP3; INFLAMMASOME; HEMOLYSIN; DISRUPTION;

D O I：

10.1016/j.chom.2012.08.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

引用

页码：266 / 275

页数：10

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