Pathogenic Pore-Forming Proteins: Function and Host Response

被引：150

作者：

Bischofberger, Mirko ^{[1
]}

Iacovache, Ioan ^{[1
]}

van der Goot, F. Gisou ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

来源：

CELL HOST & MICROBE | 2012年 / 12卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

PLASMA-MEMBRANE-REPAIR; AUREUS ALPHA-TOXIN; CHOLESTEROL-DEPENDENT CYTOLYSIN; NF-KAPPA-B; LISTERIOLYSIN-O; CASPASE-1; ACTIVATION; CELL-DEATH; NLRP3; INFLAMMASOME; HEMOLYSIN; DISRUPTION;

D O I：

10.1016/j.chom.2012.08.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

引用

页码：266 / 275

页数：10

共 116 条

[1] Adventures of a pore-forming toxin at the target cell surface [J].

Abrami, L ;

Fivaz, M ;

van der Goot, FG .

TRENDS IN MICROBIOLOGY, 2000, 8 (04) :168-172

[2] Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin [J].

Abrami, L ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 1999, 147 (01) :175-184

[3] Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores [J].

Aguilar, Jorge L. ;

Kulkarni, Ritwij ;

Randis, Tara M. ;

Soman, Sandeep ;

Kikuchi, Alexander ;

Yin, Yuxin ;

Ratner, Adam J. .

PLOS ONE, 2009, 4 (11)

[4] Blebbing confers resistance against cell lysis [J].

Babiychuk, E. B. ;

Monastyrskaya, K. ;

Potez, S. ;

Draeger, A. .

CELL DEATH AND DIFFERENTIATION, 2011, 18 (01) :80-89

[5] Intracellular Ca2+ operates a switch between repair and lysis of streptolysin O-perforated cells [J].

Babiychuk, E. B. ;

Monastyrskaya, K. ;

Potez, S. ;

Draeger, A. .

CELL DEATH AND DIFFERENTIATION, 2009, 16 (08) :1126-1134

[6] α-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells [J].

Belen Mestre, Maria ;

Fader, Claudio M. ;

Sola, Claudia ;

Isabel Colombo, Maria .

AUTOPHAGY, 2010, 6 (01) :110-125

[7] Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans [J].

Bellier, Audrey ;

Chen, Chang-Shi ;

Kao, Cheng-Yuan ;

Cinar, Hediye N. ;

Aroian, Raffi V. .

PLOS PATHOGENS, 2009, 5 (12)

[8] Some aspects of the history of membrane damaging toxins [J].

Bernheimer, AW .

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1996, 185 (02) :59-63

[9] Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles [J].

Birmingham, Cheryl L. ;

Canadien, Veronica ;

Kaniuk, Natalia A. ;

Steinberg, Benjamin E. ;

Higgins, Darren E. ;

Brumell, John H. .

NATURE, 2008, 451 (7176) :350-U13

[10] Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo [J].

Bischof, Larry J. ;

Kao, Cheng-Yuan ;

Los, Ferdinand C. O. ;

Gonzalez, Manuel R. ;

Shen, Zhouxin ;

Briggs, Steven P. ;

van der Goot, F. Gisou ;

Aroian, Raffi V. .

PLOS PATHOGENS, 2008, 4 (10)

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