Syntheses and structures of bicopper(II) complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide: Cytotoxic activities, and reactivities towards DNA and protein

被引:16
作者
Li, Xiao-Wen [1 ]
Li, Yan-Tuan [1 ]
Wu, Zhi-Yong [2 ]
Yan, Cui-Wei [3 ]
机构
[1] Ocean Univ China, Marine Drug & Food Inst, Qingdao, Peoples R China
[2] Ocean Univ China, Key Lab Marine Drug, Chinese Minist Educ, Qingdao, Peoples R China
[3] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China
关键词
Crystal structure; Bicopper(II) complex; Dissymmetrical N; N; '-bis(substituted)oxamide; Cytotoxic activity; DNA interaction; Protein binding ability; BOVINE SERUM-ALBUMIN; BINUCLEAR COPPER(II) COMPLEX; CRYSTAL-STRUCTURE; OXAMIDATO COMPLEXES; MAGNETIC-PROPERTIES; METAL-COMPLEXES; RUTHENIUM(II) COMPLEXES; ZINC(II) COMPLEXES; CLEAVAGE ACTIVITY; RATIONAL DESIGN;
D O I
10.1016/j.ica.2012.04.032
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Two new binuclear copper(II) complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N'-[3-(dimethylamino) propyl] oxamide (H3L), and end-capped with 4,4'-dimethyl-2,2'-bipyridine (Me(2)bpy) or 2,2'-diamino-4,4'-bithiazole (dabt), respectively, namely [Cu2L(H2O)(Me(2)bpy)][Cu2L(CH3OH)(Me(2)bpy)] (ClO4)(2)(CH3OH)(0.7) (1) and [Cu2L(CH3OH)(0.25)(dabt)]ClO4 center dot(H2O)(1.5) (2), have been synthesized and characterized by single-crystal X-ray diffraction. In complex 1, the dissymmetric unit of it contains two bicopper(II) cations, the cis-L-3 ligands bridge two copper(II) ions with the corresponding separations of 5.1881(11) angstrom (Cu1 center dot center dot center dot Cu2) and 5.2193(11) angstrom (Cu3 center dot center dot center dot Cu4), respectively. In complex 2, the L-3 ligand is adopting a cis conformation with the Cu center dot center dot center dot Cu distance of 5.2409 (7) angstrom. Through pi-pi stacking and hydrogen bonding interactions, the two bicopper(II) complexes are assembled to 3D supramolecular structures. Cytotoxic activities, and the reactivities towards DNA and protein of the two bicopper(II) complexes are investigated. The results suggest that the two bicopper(II) complexes interact with HS-DNA in the mode of intercalation, and the DNA-binding abilities are consistent with cytotoxic activities following the order of 2 > 1. The protein binding ability has been monitored using bovine serum albumin (BSA) as model protein. (C) 2012 Elsevier B. V. All rights reserved.
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收藏
页码:190 / 198
页数:9
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