Gut microbiota and COVID-19: An intriguing pediatric perspective

被引:3
作者
Valentino, Maria Sole [1 ]
Esposito, Claudia [1 ]
Colosimo, Simone [1 ]
Caprio, Angela Maria [1 ]
Puzone, Simona [1 ]
Guarino, Stefano [1 ]
Marzuillo, Pierluigi [1 ]
Del Giudice, Emanuele Miraglia [1 ]
Di Sessa, Anna [1 ,2 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Woman Child Gen & Specialized Surg, I-80138 Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Woman Child Gen & Specialized Surg, Via Crecchio 2, I-80138 Naples, Italy
关键词
Gut; Microbiota; Dysbiosis; Microbiome; COVID-19; Children; CESAREAN-SECTION; RISK; DELIVERY; RESPONSES; DISEASE; MODE;
D O I
10.12998/wjcc.v10.i23.8076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gastrointestinal (GI) involvement has been reported in approximately 50% of patients with coronavirus disease 2019 (COVID-19), which is due to the pathogenic role of inflammation and the intestinal function of the angiotensin-converting enzyme 2 and its receptor. Accumulating adult data has pointed out that gut dysbiosis might occur in these patients with a potential impact on the severity of the disease, however the role of gut microbiota in susceptibility and severity of COVID-19 disease in children is still poorly known. During the last decades, the crosstalk between gut and lung has been largely recognized resulting in the concept of "gut-lung axis" as a central player in modulating the development of several diseases. Both organs are involved in the common mucosal immune system (including bronchus-associated and gut-associated lymphoid tissues) and their homeostasis is crucial for human health. In this framework, it has been found that the role of GI dysbiosis is affecting the homeostasis of the gut-liver axis. Of note, a gut microbiome imbalance has been linked to COVID-19 severity in adult subjects, but it remains to be clarified. Based on the increased risk of inflammatory diseases in children with COVID-19, the potential correlation between gut microbiota dysfunction and COVID-19 needs to be studied in this population. We aimed to summarize the most recent evidence on this striking aspect of COVID-19 in childhood.
引用
收藏
页码:8076 / 8087
页数:12
相关论文
共 50 条
[41]   COVID-19, Anosmia, and Allergies: Is There a Relationship? A Pediatric Perspective [J].
Brindisi, Giulia ;
Spalice, Alberto ;
Anania, Caterina ;
Bonci, Flaminia ;
Gori, Alessandra ;
Capponi, Martina ;
Cinicola, Bianca ;
De Castro, Giovanna ;
Martinelli, Ivana ;
Pulvirenti, Federica ;
Matera, Luigi ;
Mancino, Enrica ;
Guido, Cristiana Alessia ;
Zicari, Anna Maria .
JOURNAL OF CLINICAL MEDICINE, 2022, 11 (17)
[42]   Gut microbiota, inflammatory proteins and COVID-19: a Mendelian randomisation study [J].
Chen, Yuling ;
Chen, Chang .
FRONTIERS IN IMMUNOLOGY, 2024, 15
[43]   COVID-19 Pediatric Dermatology [J].
Neale, Holly ;
Hawryluk, Elena B. .
DERMATOLOGIC CLINICS, 2021, 39 (04) :505-519
[44]   Gut Microbiota, NAFLD and COVID-19: A Possible Interaction [J].
Finelli, Carmine .
OBESITIES, 2022, 2 (02) :215-221
[45]   COVID-19 in the pediatric patient [J].
de los Angeles del Campo-Martinez, Ma ;
Sanchez-Jara, Berenice ;
Lopez-Santiago, Norma C. ;
Lozano-Garciduenas, Monica ;
Soto-Padilla, Janet M. ;
Mansheca Moreno-Gonzalez, A. ;
Guadalupe Ortiz-Torres, Ma ;
Gonzalez-Llano, Oscar ;
Reyes-Espinoza, Elio A. ;
Munoz-Juarez-Diaz, Lucia M. ;
Velazquez-Marmolejo, Lissette .
GACETA MEDICA DE MEXICO, 2021, 157 :120-130
[46]   Gut Microbiota Status in COVID-19: An Unrecognized Player? [J].
Zeppa, Sabrina Donati ;
Agostini, Deborah ;
Piccoli, Giovanni ;
Stocchi, Vilberto ;
Sestili, Piero .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10
[47]   The Gut Microbiota of Critically Ill Patients With COVID-19 [J].
Gaibani, Paolo ;
D'Amico, Federica ;
Bartoletti, Michele ;
Lombardo, Donatella ;
Rampelli, Simone ;
Fornaro, Giacomo ;
Coladonato, Simona ;
Siniscalchi, Antonio ;
Re, Maria Carla ;
Viale, Pierluigi ;
Brigidi, Patrizia ;
Turroni, Silvia ;
Giannella, Maddalena .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11
[48]   The gut microbiota as an early predictor of COVID-19 severity [J].
Fabbrini, Marco ;
D'Amico, Federica ;
van der Gun, Bernardina T. F. ;
Barone, Monica ;
Conti, Gabriele ;
Roggiani, Sara ;
Wold, Karin I. ;
Vincenti-Gonzalez, Maria F. ;
de Boer, Gerolf C. ;
Veloo, Alida C. M. ;
van der Meer, Margriet ;
Righi, Elda ;
Gentilotti, Elisa ;
Gorska, Anna ;
Mazzaferri, Fulvia ;
Lambertenghi, Lorenza ;
Mirandola, Massimo ;
Mongardi, Maria ;
Tacconelli, Evelina ;
Turroni, Silvia ;
Brigidi, Patrizia ;
Tami, Adriana .
MSPHERE, 2024, 9 (10)
[49]   Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19 [J].
Chen, Jiezhong ;
Vitetta, Luis .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (13)
[50]   Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms [J].
de Almeida, Viviani ;
Engel, Daiane F. ;
Ricci, Mayra F. ;
Cruz, Clenio Silva ;
Lopes, Icaro Santos ;
Alves, Daniele Almeida ;
D' Auriol, Mirna ;
Magalhaes, Joao ;
Machado, Elayne C. ;
Rocha, Victor M. ;
Carvalho, Toniana G. ;
Lacerda, Larisse S. B. ;
Pimenta, Jordane C. ;
Aganetti, Mariana ;
Zuccoli, Giuliana S. ;
Smith, Bradley J. ;
Carregari, Victor C. ;
Rosa, Erika da Silva ;
Galvao, Izabela ;
Cassali, Geovanni Dantas ;
Garcia, Cristiana C. ;
Teixeira, Mauro Martins ;
Andre, Leiliane C. ;
Ribeiro, Fabiola Mara ;
Martins, Flaviano S. ;
Saia, Rafael Simone ;
Costa, Vivian Vasconcelos ;
Martins-de-Souza, Daniel ;
Hansbro, Philip M. ;
Marques, Joao Trindade ;
Aguiar, Eric R. G. R. ;
Vieira, Angelica T. .
GUT MICROBES, 2023, 15 (02)