Genetics and epigenetics of hydatidiform moles

被引：7

作者：

Bestor, TH

Bourc'his, D

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

[2] Univ Paris 07, INSERM, U741, F-75251 Paris 05, France

来源：

NATURE GENETICS | 2006年 / 38卷 / 03期

关键词：

D O I：

10.1038/ng0306-274

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human embryos that develop in the presence of chromosomes solely of paternal origin give rise only to a disorganized mass of placental derivatives known as a complete hydatidiform mole. A new study reports that mutations in NALP7, a gene thought to be involved in inflammatory and apoptotic pathways, occur in human females whose biparental conceptuses can develop as apparent complete moles.

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页码：274 / 276

页数：4

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