The Potential Role of Small Nucleolar RNAs in Cancers - An Evidence Map

被引:8
作者
Wu, Fanqi [1 ]
Zhang, Longguo [2 ]
Wu, Pingfan [3 ]
Wu, Yi [2 ]
Zhang, Tao [4 ]
Zhang, Dekui [5 ]
Tian, Jinhui [6 ]
机构
[1] Lanzhou Univ Second Hosp, Dept Resp, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Clin Med Sch 2, Lanzhou, Gansu, Peoples R China
[3] 940th Hosp Joint Logist Support Peoples Liberat A, Dept Pathol, Lanzhou, Gansu, Peoples R China
[4] Lanzhou Univ Second Hosp, Dept Endocrinol & Metab, Lanzhou, Gansu, Peoples R China
[5] Lanzhou Univ Second Hosp, Dept Gastroenterol, Lanzhou, Gansu, Peoples R China
[6] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China
关键词
malignant neoplasms; snoRNAs; biomarkers; prognosis; diagnosis; PRE-MESSENGER-RNA; LUNG-CANCER; NONCODING RNAS; RIBOSOMAL-RNA; SNORNA U50; EXPRESSION; PROMOTES; GENE; IDENTIFICATION; PROLIFERATION;
D O I
10.2147/IJGM.S352333
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Cancer seriously endangers human health in every country of the world. New evidence shows that small nucleolar RNAs play important roles in tumorigenesis. Herein, we created this evidence map to systematically assess the impact of dysregulated snoRNAs on cancers. Methods: We searched four databases to February 2022 using the keywords, "carcinoma", "neoplasms", "tumor", "cancer", "snoRNA", and "small nucleolar rna". The research data were independently screened by two reviewers. Bubble plot, mind map, heatmap were used to depict the relationship between snoRNAs and cancers. Results: In total, 102 studies met the inclusion criteria and were analyzed in this evidence map. In this study, we found that dysregulated snoRNAs were statistically associated with the clinicopathological characteristics of cancer patients, and affected tumor cell phenotypes. Abnormally expressed snoRNAs were associated with poor survival in cancer patients. Current research confirmed that snoRNAs have good diagnostic efficiency for cancers. snoRNAs could modulate biological processes and signaling pathways of different cancer cells by altering rRNA, regulating mRNA, and recruiting protein factors. Conclusion: Taken all together, ectopic snoRNAs may serve as new biomarkers for clinical assessment, diagnostic, prognostic prediction of cancer patients, and provide a potential therapeutic strategy for cancer treatment. This article provided a visual analysis of existing evidence on snoRNAs and cancers, which can offer useful information for different researchers interested in snoRNAs.
引用
收藏
页码:3851 / 3864
页数:14
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