Performance variability during a multitrial list-learning task as a predictor of future cognitive decline in healthy elders

被引：10

作者：

Sugarman, Michael A. ^{[1
]}

Woodard, John L. ^{[1
]}

Nielson, Kristy A. ^{[2
]}

Smith, J. Carson ^{[3
]}

Seidenberg, Michael ^{[4
]}

Durgerian, Sally ^{[5
]}

Norman, Andria L. ^{[1
]}

Hantke, Nathan C. ^{[2
]}

Rao, Stephen M. ^{[6
]}

机构：

[1] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA

[2] Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA

[3] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA

[4] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL USA

[5] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA

[6] Cleveland Clin, Neurol Inst, Cleveland, OH 44195 USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2014年 / 36卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Cognitive aging; Intraindividual variability; Rey Auditory Verbal Learning Test; Prediction of decline; AGE; DECOMPOSITION;

D O I：

10.1080/13803395.2013.877875

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Introduction: In clinical settings, neuropsychological test performance is traditionally evaluated with total summary scores (TSS). However, recent studies demonstrated that indices of intraindividual variability (IIV) yielded unique information complementing TSS. This 18-month longitudinal study sought to determine whether IIV indices derived from a multitrial list-learning test (the Rey Auditory Verbal Learning Test) provided incremental utility in predicting cognitive decline in older adults compared to TSS. Method: Ninety-nine cognitively intact older adults (aged 65 to 89 years) underwent neuropsychological testing (including the Rey Auditory Verbal Learning Test) at baseline and 18-month follow-up. Participants were classified as cognitively stable (n = 65) or declining (n = 34) based on changes in their neuropsychological test performance. Logistic regression modeling tested the ability of baseline TSS indices (sum of Trials 1-5, immediate recall, and delayed recall) and IIV indices (lost access and gained access) to discriminate between stable and declining individuals. Results: Higher values of both lost access and gained access at baseline were associated with an increased risk for decline at 18-month follow-up. Further, the IIV indices provided predictive utility above and beyond the TSS indices. Conclusion: These results highlight the value of analyzing IIV in addition to TSS during neuropsychological evaluation in older adults. High levels of IIV may reflect impairment in anterograde memory systems and/or executive dysfunction that may serve as a prognostic indicator of cognitive decline.

引用

页码：236 / 243

页数：8