Steroid receptor control of reproductive behavior

被引：32
作者：
Auger, AP [1 ]
机构：
[1] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA
来源：
HORMONES AND BEHAVIOR | 2004年 / 45卷 / 03期
关键词：
steroid; reproductive behavior; hormones; ligand-independent;
D O I：
10.1016/j.yhbeh.2003.09.013
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Steroid hormone receptors in the brain were thought to be only activated by steroid hormones. Once steroid binds to the receptor, it would act on DNA to regulate gene transcription. Recent data indicate that steroid receptor action is more complex. Steroid receptor activity in the brain is under the control of co-regulatory proteins, such as coactivators. It is the expression of these additional proteins that modulate the activity of steroid receptors. Furthermore, steroid receptors are not only activated by steroid, but can also be activated by neurotransmitters in the absence of steroid. For example, progestin receptors in rodent brain are sensitive to progesterone and to social cues in the environment. This review discusses these emerging mechanisms for steroid receptor control in developing and adult brain. (C) 2004 Elsevier Inc. All rights reserved.
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收藏
页码：168 / 172
页数：5
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