Haemaphysalis longicornis Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China

被引:228
作者
Luo, Li-Mel [1 ]
Zhao, Li [1 ]
Wen, Hong-Ling [1 ]
Zhang, Zhen-Tang [2 ]
Liu, Jian-Wei [1 ]
Fang, Li-Zhu [1 ]
Xue, Zai-Feng [2 ]
Ma, Dong-Qiang [2 ]
Zhang, Xiao-Shuang [1 ]
Ding, Shu-Jun [3 ]
Lei, Xiao-Ying [1 ]
Yu, Xue-Jie [1 ,4 ]
机构
[1] Shandong Univ, Jinan 250100, Peoples R China
[2] Huangdao Dist Ctr Dis Control & Prevent, Qingdao, Peoples R China
[3] Shandong Prov Ctr Dis Control & Prevent, Jinan, Peoples R China
[4] Univ Texas Med Branch, Galveston, TX 77555 USA
基金
中国国家自然科学基金;
关键词
SHANDONG PROVINCE; SOUTH-KOREA; PREVALENCE; BUNYAVIRUS;
D O I
10.3201/eid2110.150126
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia caused by SFTS virus (SFTSV), a newly discovered phlebovirus. The Haemaphysalis longicornis tick has been suspected to be the vector of SFTSV. To determine whether SFTSV can be transmitted among ticks, from ticks to animals, and from animals' to ticks, we conducted transmission studies between developmental stages of H. longicornis ticks and between ticks and mice. Using reverse transcription PCR, we also analyzed the prevalence of SFTSV infection among H. longicornis ticks collected from vegetation in Shandong Province, China. Our results showed a low prevalence of SFTSV among collected ticks (0.2%, 8/3,300 ticks), and we showed that ticks fed on SFTSV-infected mice could acquire the virus and transstadially and transovarially transmit it to other developmental stages of ticks. Furthermore, SFTSV-infected ticks could transmit the virus to mice during feeding. Our findings indicate ticks could serve as a vector and reservoir of SFTSV.
引用
收藏
页码:1770 / 1776
页数:7
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