Induced pluripotent stem cells in disease modelling and drug discovery

被引：388
作者：
Rowe, R. Grant [1 ,2 ]
Daley, George Q. [1 ,2 ]
机构：
[1] Boston Childrens Hosp, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
来源：
NATURE REVIEWS GENETICS | 2019年 / 20卷 / 07期
关键词：
NATURAL-KILLER-CELLS; IN-VIVO MODEL; HEMATOPOIETIC STEM; T-CELLS; DIRECTED DIFFERENTIATION; NEURAL PROGENITORS; CEREBRAL ORGANOIDS; GENETIC-VARIATION; CLOSTRIDIUM-DIFFICILE; HUMAN LIVER;
D O I：
10.1038/s41576-019-0100-z
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. Early studies using directed differentiation of iPSCs frequently uncovered cell-level phenotypes in monogenic diseases, but translation to tissue-level and organ-level diseases has required development of more complex, 3D, multicellular systems. Organoids and human-rodent chimaeras more accurately mirror the diverse cellular ecosystems of complex tissues and are being applied to iPSC disease models to recapitulate the pathobiology of a broad spectrum of human maladies, including infectious diseases, genetic disorders and cancer.
引用
收藏
页码：377 / 388
页数：12
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