Analysis of enterovirus types in patients with symptoms of aseptic meningitis in 2014 in Shandong, China

被引：20

作者：

Chen, Peng ^{[1
]}

Lin, Xiaojuan ^{[2
,3
]}

Liu, Guifang ^{[2
,3
]}

Wang, Suting ^{[2
,3
]}

Song, Lizhi ^{[2
,3
]}

Tao, Zexin ^{[2
,3
]}

Xu, Aiqiang ^{[1
,2
,3
]}

机构：

[1] Shandong Univ, Sch Publ Hlth, Dept Epidemiol, 44 Wenhuaxi Rd, Jinan, Shandong, Peoples R China

[2] Shandong Ctr Dis Control & Prevent, Shandong Prov Key Lab Infect Dis Control & Preven, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Acad Prevent Med, Jinan, Shandong, Peoples R China

来源：

VIROLOGY | 2018年 / 516卷

基金：

中国国家自然科学基金;

关键词：

Enterovirus; Aseptic meningitis; Phylogeny; Nervous system; ECHOVIRUS; 6; ENVIRONMENTAL SURVEILLANCE; PROVINCE; OUTBREAK; IDENTIFICATION; PARECHOVIRUS; SEQUENCE;

D O I：

10.1016/j.virol.2018.01.022

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We reviewed the epidemiological and clinical characteristics of 927 aseptic meningitis patients in Shandong in 2014, and the phylogeny of predominant enterovirus (EV) types causing this disease was analyzed. A total of 209 patients that were positive for EV were identified by both cell culture and a reverse transcription-seminested PCR in cerebrospinal fluid samples. The positive patients were most likely to be children within 15 years of age, had symptoms such as fever, vomiting and nausea (P < .05). The 209 EV sequences belonged to 11 types, and coxsackievirus 85, echovirus types 6 and 30 were predominant types. VP1 analysis exhibited multiple lineages were co-circulating. The significance of the study could come from the fact that surveillance is important to monitor the prevalence of EV types in population, which shows enterovirus meningitis maintains an important public health problem in China.

引用

页码：196 / 201

页数：6

共 28 条

[11] Molecular epidemiology and genetic diversity of echovirus type 30 (E30): Genotypes correlate with temporal dynamics of E30 isolation [J].

Oberste, MS ;

Maher, K ;

Kennett, ML ;

Campbell, JJ ;

Carpenter, MS ;

Schnurr, D ;

Pallansch, MA .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (12) :3928-3933

[12] Molecular evolution of the human enteroviruses: Correlation of serotype with VP1 sequence and application to picornavirus classification [J].

Oberste, MS ;

Maher, K ;

Kilpatrick, DR ;

Pallansch, MA .

JOURNAL OF VIROLOGY, 1999, 73 (03) :1941-1948

[13]

Pallansch M.A., 2013, FIELDS VIROLOGY, P491

[14] MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods [J].

Tamura, Koichiro ;

Peterson, Daniel ;

Peterson, Nicholas ;

Stecher, Glen ;

Nei, Masatoshi ;

Kumar, Sudhir .

MOLECULAR BIOLOGY AND EVOLUTION, 2011, 28 (10) :2731-2739

[15] Cluster of human parechovirus infections as the predominant cause of sepsis in neonates and infants, Leicester, United Kingdom, 8 May to 2 August 2016 [J].

Tang, J. W. ;

Holmes, C. W. ;

Elsanousi, F. A. ;

Patel, A. ;

Adam, F. ;

Speight, R. ;

Shenoy, S. ;

Bronnert, D. ;

Stiefel, G. ;

Sundaram, P. ;

Pande, S. ;

Sridhar, A. ;

Kairamkonda, V. ;

Bandi, S. .

EUROSURVEILLANCE, 2016, 21 (34) :2-5

[16] Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006-2012 [J].

Tao, Zexin ;

Wang, Haiyan ;

Li, Yan ;

Liu, Guifang ;

Xu, Aiqiang ;

Lin, Xiaojuan ;

Song, Lizhi ;

Ji, Feng ;

Wang, Suting ;

Cui, Ning ;

Song, Yanyan .

PLOS ONE, 2014, 9 (02)

[17] Coxsackievirus B3, Shandong Province, China, 1990-2010 [J].

Tao, Zexin ;

Song, Yanyan ;

Li, Yan ;

Liu, Yao ;

Jiang, Ping ;

Lin, Xiaojuan ;

Liu, Guifang ;

Song, Lizhi ;

Wang, Haiyan ;

Xu, Aiqiang .

EMERGING INFECTIOUS DISEASES, 2012, 18 (11) :1865-1867

[18] Intercity Spread of Echovirus 6 in Shandong Province, China: Application of Environmental Surveillance in Tracing Circulating Enteroviruses [J].

Tao, Zexin ;

Song, Yanyan ;

Wang, Haiyan ;

Zhang, Yong ;

Yoshida, Hiromu ;

Ji, Shengxiang ;

Xu, Aiqiang ;

Song, Lizhi ;

Liu, Yao ;

Cui, Ning ;

Ji, Feng ;

Li, Yan ;

Chen, Peng ;

Xu, Wenbo .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2012, 78 (19) :6946-6953

[19] Cocirculation of Two Transmission Lineages of Echovirus 6 in Jinan, China, as Revealed by Environmental Surveillance and Sequence Analysis [J].

Tao, Zexin ;

Wang, Haiyan ;

Li, Yan ;

Xu, Aiqiang ;

Zhang, Yong ;

Song, Lizhi ;

Yoshida, Hiromu ;

Xu, Qing ;

Yang, Jing ;

Zhang, Yan ;

Liu, Yao ;

Feng, Lei ;

Xu, Wenbo .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 77 (11) :3786-3792

[20] Prevalence, type and concentration of human enterovirus and parechovirus in cerebrospinal fluid samples of pediatric patients over a 10-year period: a retrospective study [J].

Vollbach, Silke ;

Mueller, Andreas ;

Drexler, Jan Felix ;

Simon, Arne ;

Drosten, Christian ;

Eis-Huebinger, Anna Maria ;

Panning, Marcus .

VIROLOGY JOURNAL, 2015, 12

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