Anti-inflammatory Dendranacetylene A, a new polyacetylene glucoside from the flower of Chrysanthemum morifolium Ramat

被引：10
作者：
Li, Meng [1 ,2 ]
Zeng, Mengnan [1 ,2 ]
Zhang, Jingke [1 ,2 ]
Shi, Jingya [1 ,2 ]
Lv, Jinjin [1 ,2 ]
Tang, Yingying [1 ,2 ]
Zheng, Xiao-ke [1 ,2 ]
Feng, Wei-sheng [1 ,2 ]
机构：
[1] Henan Univ Chinese Med, Zhengzhou, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov, Zhengzhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 24期
关键词：
Chrysanthemum morifolium Ramat; polyacetylene glucoside; structural elucidation; RAW264.7 murine macrophage cells; anti-inflammatory activity; GLYCOSIDES;
D O I：
10.1080/14786419.2020.1825425
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new polyacetylene glucoside, Dendranacetylene A (1), and a known compound 8E-decaene-4,6-diyn-1-O-beta-d-glucopyranosyl-(1 ''-> 2 '')-beta-D-glucopyranoside (2) were isolated from the flowers ofDendranthema morifolium(Ramat.) kitam. The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and comparing these results with data reported in literatures. Additionally, the anti-inflammatory effects of compounds 1 and 2 were evaluated on RAW264.7 murine macrophage cells induced by lipopolysaccharide (LPS). The two compounds significantly inhibited the NO production in LPS-induced RAW 264.7 murine macrophage cells and exhibited anti-inflammatory effects.
引用
收藏
页码：5692 / 5698
页数：7
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